Mechanisms of host defense against pulmonaryinfection, inflammation and injury by surfactant proteins and studies on clinical applications

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Pulmonary surfactant is composed of lipids and proteins, and plays important roles in alveolar stability and in host defense of respiratory system. In this study, we made specific antibody against human SP-C, which can be used for clinical applications. In addition, SP-A and SP-D, pulmonary collectins, have been shown to directly bind to Legionella pneumophila and Mycobacterium avium, suppress their growth and inhibit cellular injuries caused by these bacteria. SP-D has been found to inhibit matrix metallo-proteinase activity in alveolar macrophages, These results established the molecular bases for clinical applications of the uses of surfactant proteins.