The analysis of cellular stress response towards novel conservative therapies for joint disease

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When heat shock protein 70(HSP70), a molecular chaperone, was induced in chondrocytes as a stress response mechanism under hypoxic condition, the expression of extracellular matrix gene were increased, and the chondrocytes were protected. We developed the efficiently and safe methods that supplementation of glutamine in combination with moderate heat treatment using a microwave applicator induced sufficient increased of HSP70 for therapeutic purposes in vivo. These findings showed that controlling HSP70 expression in the cartilage using supplementation of glutamine in combination with thermotherapy might offer a novel strategy for suppressing cartilage degeneration in osteoarthritis.