Analysis of inhaled anesthetics on the analgesic effect and immobilization in the spinal cord

全身麻醉药具有催眠、健忘、镇痛、不动等作用。为了阐明一氧化二氮和氙气对脊髓背角神经元的影响，我们进行了电生理实验。我们发现一氧化二氮对背角神经元的抑制性突触传递没有影响。此外，氙气还抑制了背角神经元的兴奋性传递，但不抑制传递，从而产生了抗伤害效应。

General anesthetics have the actions of hypnosis, amnesia, analgesia and immobility. To elucidate the effects of nitrous oxide and xenon in spinal dorsal horn neurons, we conducted the electrophysiological experiments. We revealed that nitrous oxide had no effects on the inhibitory synaptic transmission in dorsal horn neurons. In addition, xenon inhibited excitatory but not inhibitory transmission in dorsal horn neurons, leading to the antinociceptive effect.