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Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis

Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis
前列腺癌易感性的遗传分析进行全基因组纯合单倍型分析
批准号:
20390419
负责人:
SUZUKI Kazuhiro
金额:
$9.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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英文摘要
We analyzed the genomic DNA using genomewide homozyosity haplotype analysis to identify the susceptibility gene for familial/hereditary prostate cancer. Through previous studies and the present study, we found the significant association of prostate cancer risk with the gene encoding squalene synthase, i.e., farnesyldiphosphate farnesyltrasfrerase (FDFT1). The AA+AG genotypes of SNP in the promoter region, rs2645429 was found significantly in patients with cases. Functional analysis of FDFT1 showed the elevation of promoter activity in the A type promoter, and that the squalene synthase has close relations to prostate cancer growth.
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High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent machanism.
高密度脂蛋白通过 ABCA1 依赖性机制诱导人前列腺雄激素非依赖性癌细胞的增殖和迁移。
DOI: --
发表时间: 2010
期刊: Mel Cancer Res 8(9)
影响因子: --
作者: [Sekine Y, Demosky SJ, Stonik JA, Furuya Y, Koike H, Suzuki K, Remaley AT]
通讯作者: Remaley AT
High density lipoprotein induces proliferation and migration of human nrostate cancer cells by an ARCAI-denedent mechanism
高密度脂蛋白通过 ARCAI 机制诱导人前列腺癌细胞的增殖和迁移
DOI: --
发表时间: 2010
期刊: Mol Cancer Res
影响因子: 5.2
作者: [Sekine Y, et al(全7名)]
通讯作者: et al(全7名)
高脂肪食によるマウス前立腺における遺伝子変化の解析
高脂饮食诱导小鼠前列腺基因变化分析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [関根芳岳, 他(全5名)]
通讯作者: 他(全5名)
Survivin is associated with cell proliferation and plays a role in 1a,25-dihydrovitamin D3 induced cell growth inhibition in prostate cancer.
生存素与细胞增殖相关,并在 1a,25-二氢维生素 D3 诱导的前列腺癌细胞生长抑制中发挥作用。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Koike H, Sekine Y, Morikawa Y, Arai S, Furuya Y, Matsui H, Shibata Y, Suzuki K]
通讯作者: Suzuki K
18
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    • 批准号:
      24790470
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
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    • 财政年份:
      2012
    • 负责人:
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    • 依托单位:
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    • 批准号:
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    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.82万
    • 财政年份:
      2011
    • 负责人:
      SUZUKI Kazuhiro
    • 依托单位:
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