Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis
Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis
批准号:
20390419
负责人:
SUZUKI Kazuhiro
金额:
$9.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We analyzed the genomic DNA using genomewide homozyosity haplotype analysis to identify the susceptibility gene for familial/hereditary prostate cancer. Through previous studies and the present study, we found the significant association of prostate cancer risk with the gene encoding squalene synthase, i.e., farnesyldiphosphate farnesyltrasfrerase (FDFT1). The AA+AG genotypes of SNP in the promoter region, rs2645429 was found significantly in patients with cases. Functional analysis of FDFT1 showed the elevation of promoter activity in the A type promoter, and that the squalene synthase has close relations to prostate cancer growth.
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High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent machanism.
高密度脂蛋白通过 ABCA1 依赖性机制诱导人前列腺雄激素非依赖性癌细胞的增殖和迁移。
DOI:
--
发表时间:
2010
期刊:
Mel Cancer Res 8(9)
影响因子:
--
作者:
[Sekine Y, Demosky SJ, Stonik JA, Furuya Y, Koike H, Suzuki K, Remaley AT]
通讯作者:
Remaley AT
High density lipoprotein induces proliferation and migration of human nrostate cancer cells by an ARCAI-denedent mechanism
高密度脂蛋白通过 ARCAI 机制诱导人前列腺癌细胞的增殖和迁移
DOI:
--
发表时间:
2010
期刊:
Mol Cancer Res
影响因子:
5.2
作者:
[Sekine Y, et al(全7名)]
通讯作者:
et al(全7名)
高脂肪食によるマウス前立腺における遺伝子変化の解析
高脂饮食诱导小鼠前列腺基因变化分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[関根芳岳, 他(全5名)]
通讯作者:
他(全5名)
Survivin is associated with cell proliferation and plays a role in 1a,25-dihydrovitamin D3 induced cell growth inhibition in prostate cancer.
生存素与细胞增殖相关,并在 1a,25-二氢维生素 D3 诱导的前列腺癌细胞生长抑制中发挥作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Koike H, Sekine Y, Morikawa Y, Arai S, Furuya Y, Matsui H, Shibata Y, Suzuki K]
通讯作者:
Suzuki K
Association between common sequence variants in the FDFT1 gene and the prostate cancer risk in the Japanese population.
FDFT1 基因中常见序列变异与日本人群前列腺癌风险之间的关联。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Fukuma Y, Matsui H, Hamano T, Ohtake N, Nakata S, Suzuki K]
通讯作者:
Suzuki K
共 18 条
Elucidation of the molecular basis of carbonyl stress related to social stress resilience
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批准号:18K15354
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项目类别:Grant-in-Aid for Early-Career Scientists
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资助金额:$2.75万
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财政年份:2018
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负责人:SUZUKI Kazuhiro
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Novel mechanism for the regulation of lymphocyte dynamics
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批准号:24790470
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财政年份:2012
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Effects of lifestyle education and physical fitness program during childhood and adolescence: follow-up study of Japanese children and adolescents
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批准号:23300224
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2011
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负责人:SUZUKI Kazuhiro
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The role of lipid metabolism in prostate cancer
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批准号:23390378
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.82万
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财政年份:2011
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负责人:SUZUKI Kazuhiro
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依托单位:
Geology of the Proterozoic basement rocks and Permo-Triassic allochthons in the Geonggi massif, Korean Peninsula
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批准号:21540471
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2009
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New colored graphs towards a Brualdi-Hollingsworth conjecture
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批准号:21740085
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2009
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负责人:SUZUKI Kazuhiro
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依托单位:
Application and evaluation of educational practice for improving lifestyle and physical fitness program in Japanese school children
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批准号:20300205
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2008
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负责人:SUZUKI Kazuhiro
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依托单位:
A substantial study about the practice model construction forcollaboration of community
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批准号:20791755
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资助金额:$1.58万
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负责人:SUZUKI Kazuhiro
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依托单位:
Reexamination of CHIME ages measured on rocks from orogenic belts in the Japanese Islands and the eastern margin of Asian Continent
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批准号:19340149
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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财政年份:2007
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负责人:SUZUKI Kazuhiro
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依托单位:
Genetic analysis of prostate cancer : identification of susceptibility gene in 1p36 and 8p23 loci
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批准号:17390436
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.4万
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财政年份:2005
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负责人:SUZUKI Kazuhiro
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依托单位:
Denudation of the Ryoke metamorphic belt ; timing of ductile deformation revealed by CHIME monazite dating of granitic veins
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批准号:16340153
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.18万
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财政年份:2004
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负责人:SUZUKI Kazuhiro
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依托单位:
Genetic analysis of prostate cancer : comprehensive assessment of genetic polymorphisms and application to genetic diagnosis
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批准号:15390484
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.72万
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财政年份:2003
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依托单位:
The roles of cofilin and LIM-kinase in chemotaxis of phagocytes
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批准号:15590090
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
-
财政年份:2003
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负责人:SUZUKI Kazuhiro
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依托单位:
Fundamental study for pathophysiology of human prostate hyperplasia in respect to gene expression profiles of proliferation/apoptosis related genes
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批准号:12470328
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.47万
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财政年份:2000
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负责人:SUZUKI Kazuhiro
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依托单位:
Correlation of Late Permian basement rocks in the eastern margin of Asian continent on the basis of the CHIME dking
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批准号:12640442
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2000
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负责人:SUZUKI Kazuhiro
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依托单位:
geochronological analysis of the evolutional history of basement rocks in the Japanese Islands
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批准号:09640568
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:SUZUKI Kazuhiro
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依托单位:
Studies on roles of cofilin (actin/PIP2-binding protein) in activation of phagocytes
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批准号:08672551
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.64万
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财政年份:1996
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负责人:SUZUKI Kazuhiro
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依托单位:
Comparison of New England Orogen and Japanese terranes
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批准号:06045017
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.37万
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财政年份:1994
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负责人:SUZUKI Kazuhiro
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依托单位:
Analysis of consolidation processes of granitic magma based on partition of rare earth elements between accessory minerals
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批准号:04402016
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$15.62万
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财政年份:1992
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负责人:SUZUKI Kazuhiro
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依托单位:
Behavior of trace elements concentrated at grain-boundaries during partial melting of Peridotites
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批准号:63460053
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$5.5万
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财政年份:1988
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负责人:SUZUKI Kazuhiro
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依托单位:
海外基金