Development of new materials for caries treatment using human phosphophoryn-derived RGD-containing peptide

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The aim of this study is to development of new materials and method for deep-caries treatment which is reliable and safe. First, we synthesized peptide including RGD existing in N-terminal of phosphophoryn (dentin phosphoprotein) that possesses dentin induction activity. As a carrier of phosphophoryn, we used type I collagen indicating biocompatibility in this study. As a result, peptide I was found to induce large amount of reparative dentin having high density. Therefore, it was suggested that peptide I/collagen composite may be possible to be used as a new material for deep-caries treatment.