The development of non-surgical preprosthodontic bone augmentation procedure for the strategic prosthodontic treatment

本研究的目的是在不使用人工、外源性或自体骨替代物的情况下，实现口腔修复前骨增量。在几种药物递送系统中，从骨促进药物他汀的持久性和缓释能力的角度来看，由去端胶原和α-TCP组成的化合物和聚（乳酸-共-乙醇酸）（PLGA）上级其他药物。他汀-胶原-磷酸三钙复合物和他汀浸渍的PLGA在体外对成骨细胞分化有促进作用，在大鼠模型中具有成骨能力。

The aim of this study was to achieve preprosthodontic bone augmentation without using artificial, exogenous or autogenous bone substitute. Among several drug delivery systems, a compound consisted of atelocollagen and alpha-TCP, and poly (lactic-co-glycolic acid) (PLGA) were superior to others from the point of view of persistence and sustained-release capability of statin, a bone promotive drug. Both statin-collagen-TCP complex and statin-impregnated PLGA had a promotive effect on osteoblastic cell differentiation in vitro, and they had a bone formation capacity in rat model.