The development of non-surgical preprosthodontic bone augmentation procedure for the strategic prosthodontic treatment

本研究的目的是在不使用人工、外源性或自体骨替代物的情况下实现修复前骨增强。在几种给药系统中，他汀类促骨药物的持久性和缓释能力较好，其中由胶原蛋白和α - tcp组成的复合物和聚乳酸-羟基乙酸（PLGA）。他汀-胶原- tcp复合物和他汀浸渍PLGA均对体外成骨细胞分化有促进作用，并在大鼠模型中具有成骨能力。

The aim of this study was to achieve preprosthodontic bone augmentation without using artificial, exogenous or autogenous bone substitute. Among several drug delivery systems, a compound consisted of atelocollagen and alpha-TCP, and poly (lactic-co-glycolic acid) (PLGA) were superior to others from the point of view of persistence and sustained-release capability of statin, a bone promotive drug. Both statin-collagen-TCP complex and statin-impregnated PLGA had a promotive effect on osteoblastic cell differentiation in vitro, and they had a bone formation capacity in rat model.