The development of non-surgical preprosthodontic bone augmentation procedure for the strategic prosthodontic treatment

用于策略性修复治疗的非手术修复前骨增量手术的发展

• 批准号: 20390490
• 负责人: AYUKAWA Yasunori
• 金额: $ 12.15万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390490/
• 关键词: 補綴前骨再生; トップダウントリートメント; インプラント; トップダイントリートメント

The aim of this study was to achieve preprosthodontic bone augmentation without using artificial, exogenous or autogenous bone substitute. Among several drug delivery systems, a compound consisted of atelocollagen and alpha-TCP, and poly (lactic-co-glycolic acid) (PLGA) were superior to others from the point of view of persistence and sustained-release capability of statin, a bone promotive drug. Both statin-collagen-TCP complex and statin-impregnated PLGA had a promotive effect on osteoblastic cell differentiation in vitro, and they had a bone formation capacity in rat model.

本研究的目的是在不使用人工、外源或自体骨替代物的情况下实现修复前骨增量。在几种药物递送系统中，从骨促进药物他汀类药物的持久性和缓释能力的角度来看，由去端肽胶原和α-TCP组成的化合物以及聚乳酸-乙醇酸（PLGA）优于其他药物递送系统。他汀类药物-胶原蛋白-TCP复合物和他汀类药物浸渍的PLGA均对体外成骨细胞分化有促进作用，并且在大鼠模型中具有成骨能力。

项目成果

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

• DOI: 10.1016/j.biomaterials.2010.01.016
• 发表时间: 2010-04-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Masuzaki, Tomohiro;Ayukawa, Yasunori;Koyano, Kiyoshi
• 通讯作者: Koyano, Kiyoshi

Single transdermal application of statinenhances bone healing around titanium implants in rats.

单次透皮应用他汀类药物可增强大鼠钛种植体周围的骨愈合。

• 发表时间: 2009
• 作者: Masuzaki T;Ayukawa Y;Moriyama Y;Tsukiyama Y;Koyano K.
• 通讯作者: Koyano K.

Bone engineering for dental implantology : which modalities are really potential?

用于牙科种植的骨工程：哪些方式真正具有潜力？

• 发表时间: 2010
• 作者: Hong G;Li YA;Lian YM;Sadamori S;Hamada T;Murata H;鮎川保則
• 通讯作者: 鮎川保則

Simvastatin enhances bone formation around titanium implants in rat tibiae

• DOI: 10.1111/j.1365-2842.2009.02011.x
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF ORAL REHABILITATION
• 影响因子: 2.9
• 作者: Ayukawa, Y.;Ogino, Y.;Koyano, K.
• 通讯作者: Koyano, K.

Vertical bone augmentation with fluvastatin in an injectable delivery system: a rat study

• DOI: 10.1111/j.1600-0501.2008.01665.x
• 发表时间: 2009-08-01
• 期刊: CLINICAL ORAL IMPLANTS RESEARCH
• 影响因子: 4.3
• 作者: Jinno, Yohei;Ayukawa, Yasunori;Koyano, Kiyoshi
• 通讯作者: Koyano, Kiyoshi