Tailor-made bone regeneration as a pre-prosthodontic treatment based on the concept of tissue engineering triad

基于组织工程三元组概念的定制骨再生作为修复前治疗

• 批准号: 23659902
• 负责人: AYUKAWA Yasunori
• 金额: $ 1.83万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659902/
• 关键词: 骨再生; テーラーメイド医療; ティッシュエンジニアリング; 補綴前処置

According to the principle of tissue engineering triad, cells, bioactive molecules, and scaffold are thought to be essential for regeneration. From this point, it is supposed that not every site expected to augment bone tissue requires same element.From the results of our experiments, the local application of both osteoblast-differentiation factor and osteoblast-proliferation factor could induce bone formation. But the bone induced by the former represented more mineralized bone than that induced by the latter. In addition, osteoblast-differentiation factor stimulated the Smad-signaling pathway in the osteoblast-like cells.

根据组织工程三位一体的原理，细胞、生物活性分子和支架被认为是再生所必需的。从这一点上推测，并不是每个预期增加骨组织的部位都需要相同的元素。从我们的实验结果来看，局部应用成骨细胞分化因子和成骨细胞增殖因子都可以诱导骨形成。但前者诱导的骨比后者诱导的多为矿化骨。此外，成骨细胞分化因子刺激成骨样细胞中的Smad信号通路。

项目成果

Bone regeneration of rat tibia defects with enzymatically hydrogelation of gelatin derivative and recombinant human platelet-derived growth factor-BB complex

明胶衍生物和重组人血小板衍生生长因子-BB复合物酶水凝胶法促进大鼠胫骨缺损骨再生

• 发表时间: 2013
• 期刊: Int J Oral Maxillofac Implants
• 作者: Kondo D;Ogino Y;Ayukaya Y;Sakai S;Kawakami K;Koyano K
• 通讯作者: Koyano K

酵素硬化型ゼラチン-血小板由来増殖因子複合体のインジェクション投与は低侵襲な骨増生に有効である

注射酶硬化明胶-血小板衍生生长因子复合物可有效促进微创骨生长

• 发表时间: 2011
• 作者: 近藤大介;荻野洋一郎;鮎川保則;古谷野潔
• 通讯作者: 古谷野潔