The basic study of effects of bFGF on control of post-operative scarring in cleft palate surgery

药物调节可减少后推法腭裂术后瘢痕形成的不良影响。本研究观察了大鼠上颌骨粘骨膜剥脱后即刻局部应用碱性成纤维细胞生长因子对创面愈合过程中肌成纤维细胞凋亡、胶原变化及牙槽骨生长的影响。结果表明，碱性成纤维细胞生长因子可诱导成肌成纤维细胞迅速减少，抑制胶原纤维和弹性系统纤维的生成，减轻大鼠上颌骨粘骨膜剥脱后创面愈合过程中牙弓的收缩。这些发现表明，碱性成纤维细胞生长因子有可能通过调节腭裂伤口的愈合过程来减轻腭裂术后上颌骨生长抑制。

The pharmaceutical modulation may reduce unfavorable effects of scarring after cleft palate surgery by the push-back method. This study investigated the effects of local bFGF administration immediately after mucoperiosteal denudation of rat palates on apoptosis in myofibroblasts, collagen changes and dento-alveolar growth during the wound healing. The results showed that bFGF induces rapid reductions in myofibroblasts, suppresses collagen typeIand elastic system fibers generation, and relieves dental arch constriction in the wound healing process after mucoperiosteal denudation of rat palates. These findings suggest that bFGF has the potential to reduce maxillary growth inhibition after cleft palate surgery by modulating the palatal wound healing process.