Analysis of arsenic-mediated carcinogenesis and development of a preventive therapy targeting modulation for three-dimensional structure of oncogene products.

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It has been reported that arsenic in well drinking water causes various cancers in patients with arsenicosis. Therefore, identification of arsenic-polluted well water is important. Moreover, clarification of mechanisms for arsenic-mediated cancer is also important to develop novel preventive therapies for arsenic-mediated cancers. In this study, we performed international collaboration with several universities in Asian countries and investigated levels of various elements including arsenic. We further showed that arsenic might promote carcinogenesis through cysteine-mediated modulation for three-dimensional structure of oncogene products. Based on the results, we proposed a cysteine-targeted preventive therapy for arsenic-mediated cancer.