Iron homeostasis regulated by the CCAAT-binding complex in filamentous fungi.

HapX是一种参与丝状真菌铁稳态的调节剂，对它的研究有了以下新发现。1)HapX与编码含铁蛋白质如细胞色素c的基因启动子的Hap B/C/E复合物依赖性特异性结合特性。已被阐明。2)体内分析显示HapX参与铁稳态。3)获得HapX的截短突变体和截短的重组HapX，以用于HapX的未来结构域分析。

Research on the HapX, a regulator involved in iron homeostasis in filamentous fungi led to some new findings, as follows. 1) Hap B/C/E complex-dependent specific bind- ing property of HapX to the promoters of genes coding iron containing proteins such as cytochrome c. has been elucidated. 2) In vivo analysis revealed the involvement of HapX in the iron homeostasis. 3) Truncated mutants of HapX and the truncated recombinant HapX were obtained to use for the future domain analysis of HapX.