Iron homeostasis regulated by the CCAAT-binding complex in filamentous fungi.

对HapX的研究，一种参与丝状真菌铁稳态的调节因子，导致了一些新的发现，如下所示。1)HapX依赖于HapB/C/E复合体与细胞色素C等含铁蛋白编码基因启动子的特异性结合。2)体内分析表明，HapX参与了铁的稳态。3)获得了HapX的截短突变体和截短的重组HapX，为进一步的HapX结构域分析奠定了基础。

Research on the HapX, a regulator involved in iron homeostasis in filamentous fungi led to some new findings, as follows. 1) Hap B/C/E complex-dependent specific bind- ing property of HapX to the promoters of genes coding iron containing proteins such as cytochrome c. has been elucidated. 2) In vivo analysis revealed the involvement of HapX in the iron homeostasis. 3) Truncated mutants of HapX and the truncated recombinant HapX were obtained to use for the future domain analysis of HapX.