Development of simulation method of cell group population based on signal transduction pathway's behaviors

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The computer model which simultaneously calculates intra-cellular reactions and population of cell groups was developed by constructing a model of the helper T cell differentiation. The model contained the interactions among transcription factors in Th0 and simple interactions among subtypes through cytokines. This model mimicked TCR-stimulation strength dependency and TGF-β dependency of Th17 and iTreg. To simulate such behaviors, an unknown inhibitory factor, which is induced by Foxp3 and inhibits RORγt actions, is required. The physiological role of iTreg was analyzed by the simulation of the system containing dendritic cells and nTreg.