Clarification of ATBF1 function in Alzheimer's disease

我们发现ATBF1在AD和AD模型小鼠（Tg2576）的大脑中表达上调。此外，我们的体外研究表明，Aβ和dna损伤药物，即依托opo苷和同型半胱氨酸，增加了大鼠原代皮质神经元中ATBF1的表达水平；这种增加，反过来，可能激活负责神经元死亡的ATM信号。此外，ATBF1通过与APP的相互作用增强了瞬时共转染ATBF1和APP的HEK293T细胞中Aβ的产生。

We found that ATBF1 expression was up-regulated in the brains of AD and AD model mouse (Tg2576). Moreover, our in vitro studies showed that Aβ and DNA-damaging drugs, namely, etoposide and homocysteine, increased the ATBF1 expression level in primary rat cortical neurons ; this increase, in turn, may activate ATM signaling responsible for neuronal death. In addition, ATBF1 enhanced Aβ production in HEK293T cells transiently cotransfected with ATBF1 and APP via its interaction with APP.