A study of histological grading on bone and soft tissue tumors by analysis of ATBF1

ATBF1分析骨与软组织肿瘤的组织学分级研究

• 批准号: 21590389
• 负责人: NOJIMA Takayuki
• 金额: $ 3.08万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590389/
• 关键词: 骨軟部腫瘍; 病理診断; 悪性度評価; ATBF1; 遺伝子解析; ATBF1遺伝子

ATBF1(AT-motif binding factor 1) was discovered as a transcriptional regulator of α-fetoprotein. Thereafter, ATBF1 had a regulatory mechanism of a neuronal and skeletal muscular differentiation, and was a homeotic transcriptional regulatory factor identified as a tumor suppressor gene. We analyzed an immunohistochemical expression and function of ATBF1 on bone and soft tissue tumors. As a result, nuclear staining was observed in most cases of benign or low grade malignant tumor groups, however, in high grade malignant tumor group, one case showed nuclear positivity. Comparing nuclear staining negative group with nuclear staining positive group, we can imply that ATBF1 expression may have potential as a prognostic indicator for bone and soft tissue tumors.

ATBF 1（AT-motif binding factor 1）是一种α-fetoprotein的转录调节因子。此后，ATBF 1具有神经元和骨骼肌分化的调节机制，并且是被鉴定为肿瘤抑制基因的同源异型转录调节因子。我们分析了ATBF 1在骨和软组织肿瘤中的免疫组化表达和功能。结果显示，良性或低度恶性肿瘤组的大多数病例可见细胞核染色，而高度恶性肿瘤组仅1例细胞核染色阳性。比较核染色阴性组和核染色阳性组，我们可以暗示ATBF 1表达可能作为骨和软组织肿瘤的预后指标。

项目成果

Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis

石棉沉滞症患者的原发性局限性肝脏双相性间皮瘤

• 发表时间: 2009
• 期刊: World J.Gastroentrol. 15
• 作者: 井村穣二;山岸秀嗣;冨田茂樹;市川一仁;加藤洋;藤盛孝博;M.Sasaki
• 通讯作者: M.Sasaki

ATBF1 is highly phosphorylated in embryonic brain

ATBF1 在胚胎大脑中高度磷酸化

• 发表时间: 2011
• 作者: Zhang S;Dong Y;Minato H;Nojima T;Asai K;Miura Y
• 通讯作者: Miura Y

Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation.

• DOI: 10.3892/ijo_00000707
• 发表时间: 2010-09
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: H. Nakajima;Y. Ishigaki;Qi-sheng Xia;T. Ikeda;Y. Yoshitake;H. Yonekura;T. Nojima;Takuji Tanaka;H. Umehara;N. Tomosugi;T. Takata;Takeo Shimasaki;N. Nakaya;I. Sato;K. Kawakami;K. Koizumi;T. Minamoto;Y. Motoo

Adenomatoid tumor of the pleura

• DOI: 10.1111/j.1440-1827.2009.02407.x
• 发表时间: 2009-08-01
• 期刊: PATHOLOGY INTERNATIONAL
• 影响因子: 2.2
• 作者: Minato, Hiroshi;Nojima, Takayuki;Kinoshita, Eriko
• 通讯作者: Kinoshita, Eriko

Extra-axial soft tissue chordoma of wrist

• DOI: 10.1016/j.prp.2011.02.001
• 发表时间: 2011-01-01
• 期刊: PATHOLOGY RESEARCH AND PRACTICE
• 影响因子: 2.8
• 作者: Suzuki, Hiroaki;Yamashiro, Katsushige;Usui, Masamichi
• 通讯作者: Usui, Masamichi