Role of Phosphatidylinositol Signaling in the Activation of Volume-Regulated Anion Channels

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Since it is fully unknown the mechanism in the activation of Volume-regulated anion channel (VRAC) that is an important regulator of the cell-size, I studied the relationships between VRAC activation and phosphatidylinositol signaling in mouse ventricular cells. I found the attenuation of VRAC current by PIP3 depletion in type 1 diabetic mice, the inhibition of VRAC current by a 1- adrenoceptor-mediated PIP2 depletion. In addition, preliminary data suggested that the modulation of VRAC by PIP3-PDK1-Akt signaling. These results provide novel evidences in the activation of cardiac VRAC current.