Establishment of a network of model-monkey supply forhuman medical researches

食蟹猴广泛分布于东南亚，非人灵长类动物已成为传染病和移植研究的重要动物模型。对于这些研究，有必要对其主要组织相容性复合体(MHC)多态区域进行更广泛的表征，MHC纯合子(Homo)食蟹猴将在免疫学研究中具有很大优势。我们已经从日本和东南亚的许多食蟹猴繁育设施采集了血液样本，并已启动MHC基因分析。这些动物是人工饲养的，有必要建立供应制度。这些动物的供应体系分为三个阶段，并建立起来。第一阶段：与各设施合作，共享信息资料。第二阶段：利用每个设施提供的材料建立室内人工繁殖系统。第三阶段：为利用生产的MHC鉴定猴进行研究而提供的物资。在这项研究中，我们证明了我们的模型猴供应系统和室内人工繁殖系统可以显示存活的MHC鉴定的猴子，它甚至可以工作在传染病和移植研究中。

Cynomolgus monkeys (Macaca fascicularis) live in a broad range of South-East Asia, and nonhuman primates (NHPs) have emerged as important animal models in infectious diseases and transplantation studies. For those studies, it’s necessitating a more extensive characterization of their major histocompatibility complex (MHC) polymorphic regions and MHC homozygous (homo) cynomolgus monkey would have big advantage for immunological research. We have collected a blood samples from many cynomolgus monkey breeding facilities in Japan and South-East Asia, and MHC gene analysis has been initiated. These animals are bred artificially and it is necessary to establish the system to supply. The supply system of these animals was divided into three stages, and it was established. First stage: It cooperates between with each facility and information-material was shared. Second stage: Establishment the indoor artificial breading system with the materials offered from each facility. Third stage: It supplies in order to use the produced MHC identified monkey for research. In this study, we have demonstrated our model monkey supply system followed by indoor artificial breading system could show viable MHC identified monkey and it could work even at infectious diseases and transplantation studies.