Biochemical Mechanism of Coenzyme Q Redox Cycle for Showing Decreased Fatigue During Aerobic Exercise

CoQ10在体内抗氧化活性的动力学尚未完全阐明，特别是在消除剧烈有氧运动中产生的过量氧自由基方面。本研究探讨了CoQ10对有氧游泳运动引起的氧化应激的保护作用。在给药4周后观察到辅酶q10的保护作用，如降低血清乳酸水平和血清LDH活性，延长游泳时间。此外，辅酶q10给药组NADPH-CoQ还原酶活性也有所增加。这些结果表明，辅酶q10通过NADPH-CoQ还原酶的还原形式构成了抵抗有氧运动引起的氧化应激和疲劳的基本防御系统。

The dynamics of CoQ10 antioxidant activities in vivo have not yet been fully elucidated, especially regarding the elimination of excessive oxygen radicals produced during intense aerobic exercise. The present study investigated the protective effects of CoQ10 against oxidative stress induced by aerobic swimming exercise.Protective effects of CoQ10 were observed in 4-week CoQ10 administration such as decreasing in serum lactate level and serum LDH activities, elongation swimming duration. Moreover, NADPH-CoQ reductase activity also increased in CoQ10 administration group. These results suggest that the reduced form of CoQ10 with NADPH-CoQ reductase constituted a fundamental defense system against oxidative stress and fatigue induced by aerobic exercise.