Effects of lengthening contractions on signaling molecules expressions in muscular protein synthesis and degradation

点击翻译按钮获取中文摘要

We performed eccentric contractions (ECs) with fast (180 deg/sec : 180ECs) and slow (30 deg/sec : SLOWECs) velocities on rat gastrocnemius and examined effects on protein synthesis and degradation. Obtained results are shown below. (1) 30ECs induced protein synthesis. On the other hand, 180ECs induced protein degradation. (2) Especially in 180ECs, we found evidences for both AMPK activation and sciatic nerve injury. Eccentric contractions induce either protein synthesis or degradation depending on angular velocity.