Investigation of salivary alpha-amylase activity as a stress-related biomarker and its application for stress management

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It has been proposed that salivary alpha-amylase (sAMY) is a useful stress-related biomarker, but further investigation is needed to confirm this assumption. The purpose of our cross-sectional and longitudinal studies was to evaluate whether sAMY activity was really associated with several kinds of experimental and ordinary stress or relaxation among Japanese university students and office workers. The investigated levels of sAMY showed a tendency to increase in response to stress under strict rest condition or when measured frequently. Inter-individual, and possibly intra-individual, differences in the reactivity of sAMY are considered to affect the results. It is suggested that sAMY activity is useful as a stress-related biomarker in the longitudinal, rather than cross-sectional, studies.