Relative risk factors for obesity : A pilot study of genetic polymorphisms and physical characteristics in Japanese young (<BMI25) and elderly (>BMI25) women

肥胖的相对危险因素：日本年轻（<BMI25）和老年（>BMI25）女性遗传多态性和身体特征的初步研究

• 批准号: 20500620
• 负责人: FUKE Yoko
• 金额: $ 2.58万
• 依托单位: Tokyo Metropolitan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500620/
• 关键词: 生活習慣病; 生活習慣病予防; 遺伝子多型; 爪; DNA; PPARγ; β3-AR; アディポネクチン; 体組成

This study aimed to investigate whether polymorphic variant related obesity are associated with physical characteristics on 40-60 years Japanese women (>BMI25) compared with healthy young women. The allele frequency of Pro12 of PPARγ2 were shown similar result as young women, but genotypic distribution of Trp/Arg on Arg64 of β_3-AR was lower, and G/G276 SNP of adiponectin gene was shown higher than young women. Young women who are normal weight (BMI19.9±1.60) estimating as the high risk of obesity on 3 candidate gene expression were 24%. To recognize own genetic factor participating in obesity at young time may have induced the changes in life-style to control body weight.

本研究旨在探讨与健康年轻女性相比，40-60岁日本女性（>BMI25）的多态变异相关肥胖是否与身体特征相关。PPARγ2的Pro12等位基因频率与年轻女性相似，但β_3-AR的Arg64上Trp/Arg的基因型分布较低，脂联素基因G/G276 SNP高于年轻女性。正常体重（BMI19.9±1.60）的年轻女性3个候选基因表达为肥胖高危人群的比例为24%。认识到自己的遗传因素在年轻时参与肥胖可能引起生活方式的改变，以控制体重。

项目成果

Relative risk factors for osteoporosis : a pilot study of genetic polymorphisms and bone mineral density in Japanese young women

骨质疏松症的相对危险因素：日本年轻女性遗传多态性和骨矿物质密度的初步研究

• 发表时间: 2011
• 期刊: Public Health Genomics
• 影响因子: 1.7
• 作者: Yoshie Oishi;Shoko Shinoda;Yoko Watanabe;Mamiko Naka;Yoko Fuke
• 通讯作者: Yoko Fuke

肥満に関与する遺伝子多型解析によるリスク評価と身体組成における相関性の検討

通过肥胖相关基因多态性分析检验风险评估与身体成分之间的相关性

• 发表时间: 2011
• 期刊: 日本予防医学会誌 印刷中
• 作者: 渡邊容子;篠田粧子;大石芳江;仲眞美子;福家洋子
• 通讯作者: 福家洋子