Microvascular Angina in Postmenopausal Women and Effect of Kampo Medicine

绝经后妇女微血管性心绞痛及汉方药的疗效

• 批准号: 20510248
• 负责人: NAKAGAWA MIKIKO
• 金额: $ 3万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20510248/
• 关键词: 漢方薬; 更年期; 微小血管性狭心症; 女性; 性差医療; 血管内皮機能; 東洋医学; 冠血流予備能

Microvascular angina is a condition characterized by angina-like chest pain with normal coronary angiography and mostly observed in the postmenopausal women. Keishibukuryougan (KBG) is a traditional Kampo medicine and improves microcirculation in peripheral vessel. However, its effect on the coronary microcirculation has not been evaluated. We measured the coronary flow velocity by echo-cardiography and determined the coronary flow velocity reserve before and after oral administration of KBG in young healthy volunteers. KBG significantly improved CFVR, suggested the potential therapeutic usefulness of KBG for coronary microvascular angina.

微血管性心绞痛是一种以心绞痛样胸痛为特征的疾病，冠状动脉造影正常，多见于绝经后妇女。Keishibukuryougan（KBG）是一种传统的汉方药物，可改善外周血管的微循环。然而，其对冠状动脉微循环的影响尚未得到评价。应用超声心动图测定健康青年志愿者口服KBG前后冠状动脉血流速度及血流储备。KBG显著改善CFVR，提示KBG对冠状动脉微血管性心绞痛有潜在的治疗价值。

项目成果

Acute Effect of Keishibukuryougan, a Kampo Medicine, on Coronary Flow Velocity Reserve in Normal Human Volunteer.

汉方药物 Keishibukuryougan 对正常人志愿者冠状动脉血流速度储备的急性影响。

• 发表时间: 2010
• 作者: Kaori Ezaki;Mikiko Nakagawa;et al.
• 通讯作者: et al.

Acute Effect of Keishibukuryougan, a Kampo Medicine, on Coronarv Flow Velocity Reserve in Normal Human Volunteer

汉方药物 Keishibukuryougan 对正常人志愿者冠状动脉血流速度储备的急性影响

• 发表时间: 2010
• 作者: 江崎かおり;中川幹子;他
• 通讯作者: 他