Development of chaperone-peptide beads for control of toxic nano-particle
Development of chaperone-peptide beads for control of toxic nano-particle
批准号:
20550111
负责人:
TANAKA Naoki
金额:
$3.24万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To develop chaperone-bead for detecting toxic nano-particle, the property of the chaperone peptide derived from the substrate binding site of the molecular chaperone αA-crystallin was studied. Chaperone peptide which corresponds to the residues 71-75 of αA-crystallin self-assemble into nano-scale fibril to efficiently reduce the aggregation of the substrate model protein. The substrate recognition mechanism of a the chaperon-peptide was studied.
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small HSP由来シヤペロンペプチドのアミロイド線維形成抑制機構
小HSP衍生的Shaperone肽抑制淀粉样原纤维形成的机制
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[S.Kobayashi, H.Kataoka, T.Ishizone, T.Kato, T.Ono, S.Kubotaka, K.Arimoto, H.Ogi, 田中直毅]
通讯作者:
田中直毅
シャペロンペプチドにおけるアミロイド線維能と蛋白質凝集抑制機能
伴侣肽的淀粉样原纤维能力和蛋白质聚集抑制功能
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Mori, T.; Beppu, S.; Berber, M.; Mori, H.; Makimura, T.; Tsukamoto, A.; Minagawa, K.; Hirano, T.; Tanaka, M.; Niidome, T.; Katayama, Y.; Hirano, T.; Maeda, Y., 田中直毅]
通讯作者:
田中直毅
The mechanism of fibril formation of ovalbumin revealed by the identification of amyloidogenic core regions.
通过鉴定淀粉样蛋白核心区域揭示卵清蛋白原纤维形成的机制。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Morimoto Y., Kawachi Y., Waku, T., Kunugi S., Takahashi N., Tanaka N.]
通讯作者:
Tanaka N.
ミスフォールディングを阻害するシャペロンペプチド集合体の設計
抑制错误折叠的伴侣肽整体的设计
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[N. Nishimura, Y.Hirano, 田中直毅]
通讯作者:
田中直毅
シャペロンペプチドの蛋白質凝集抑制におけるアミロイド線維形成の役割
淀粉样原纤维形成在伴侣肽抑制蛋白质聚集中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[田中直毅, 宮田慶亮, 寺村加寿人, 功刀滋]
通讯作者:
功刀滋
共 8 条
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Analysis of pathogenesis of alcoholic liver disease and development of novel therapies using PPARalpha-null mice
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Wellposedness of differential equations whose solutions depend Lipschitz continuously on their initial data
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批准号:19540177
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资助金额:$2.75万
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财政年份:2007
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依托单位:
Molecular property and functional control of chaperone-like polymer
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批准号:16550109
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资助金额:$2.37万
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Wellposedness of the Cauchy problems for hyperbolic systems with large data
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Research of Extraction Method of Road Elements from Road surface Image Based on Morphology.
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资助金额:$1.98万
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财政年份:2003
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依托单位:
Well-posedness and approximation of Cauchy problems for hyperbolic systems
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批准号:14540175
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资助金额:$2.18万
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Character and Line Figure Recognition in an Image
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批准号:10680404
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:1998
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负责人:TANAKA Naoki
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依托单位:
海外基金