Study on functional antisense nucleic acids for ncRNA
Study on functional antisense nucleic acids for ncRNA
批准号:
20550147
负责人:
OZAKI Hiroaki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Functional oligonucleotides were prepared for new antisense molecule to regulate microRNA. Incorporation of arabinonucleosides or phenanthroline-polyamine derivatives in DNA did not contribute to enhancement of antisense activity. siRNA bearing modified nucleoside was more active in silencing the gene expression. These siRNA could regulate the microRNA.
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