Mechanisms and roles on phagocytosis of microbes and altered self cells

通过吞噬作用清除有害细胞是细胞天然免疫，其分子机制和作用仍有待阐明。在本研究中，我们发现了通过德雷珀，我们检测到的吞噬受体的细胞内信号。我们还鉴定了果蝇凋亡细胞和细菌中的德雷珀配体，并认为先天免疫中的吞噬受体是一种多配体-受体。另一方面，我们鉴定了影响宿主细胞免疫和体液免疫的细菌因子，并研究了细菌逃避宿主免疫应答的策略。

Elimination of unwanted cells by phagocytosis is the cellular innate immunity, and its molecular mechanism and role have remained to be elucidated. In this study, we found out the intracellular signaling through Draper, a phagocytic receptor we have detected. We also identified Draper ligand in Drosophila apoptotic cells and bacteria, and suggested that the phagocytic receptor in innate immunity acts as a multi ligand-receptor. On the other hand, we identified bacterial factors that influenced with host cellular and humoral immunity, and examined bacterial strategy to escape from the host immune responses.