The identification of signal components and analysis of the regulatory mechanisms of WNK protein kinases, the essential genes for early development and pathogenesis of hereditary form of hypertension

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WNK kinase family that has been recently identified serine-threonine protein kinase family conserved among several multicellular organisms. There are four human WNK family members, and mutations in two of them, WNK1 and WNK4, have been linked to a hereditary form of human hypertension. Moreover, the disruption of the WNK1 gene caused death of organisms. Therefore, the elucidation of WNK signaling network is important upon clarifying the mechanism of morphogenesis, organogenesis and disease. In this research, new interacting factors of WNK were identified by biochemical, molecular biology, and genetic techniques.