The identification of signal components and analysis of the regulatory mechanisms of WNK protein kinases, the essential genes for early development and pathogenesis of hereditary form of hypertension

WNK蛋白激酶是遗传性高血压早期发生和发病机制的重要基因，信号成分鉴定及调控机制分析

• 批准号: 20570179
• 负责人: MORIGUCHI Tetsuo
• 金额: $ 3.08万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570179/
• 关键词: WNK; シグナル伝達; 疾患; 発生; がん; 初期発生

WNK kinase family that has been recently identified serine-threonine protein kinase family conserved among several multicellular organisms. There are four human WNK family members, and mutations in two of them, WNK1 and WNK4, have been linked to a hereditary form of human hypertension. Moreover, the disruption of the WNK1 gene caused death of organisms. Therefore, the elucidation of WNK signaling network is important upon clarifying the mechanism of morphogenesis, organogenesis and disease. In this research, new interacting factors of WNK were identified by biochemical, molecular biology, and genetic techniques.

WNK激酶家族是最近确定的丝氨酸-苏氨酸蛋白激酶家族，保守存在于几种多细胞生物中。人类有四个WNK家族成员，其中两个WNK1和WNK4的突变与人类高血压的遗传形式有关。此外，WNK1基因的破坏会导致生物体死亡。因此，阐明WNK信号网络对阐明细胞形态发生、器官发生和疾病发生的机制具有重要意义。本研究通过生物化学、分子生物学和遗传技术鉴定了新的WNK相互作用因子。

项目成果

KRAS/LKB1変異による肺線がん細胞のEMTとがん幹細胞マーカーの発現誘導

肺癌细胞中的 EMT 以及 KRAS/LKB1 突变诱导癌症干细胞标志物表达

• 发表时间: 2009
• 作者: Sasagawa Y;Otani M;Higashitan N;Higashitani A;Sato K;Ogura T;Yamanaka K.;森口徹生
• 通讯作者: 森口徹生

Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells

• DOI: 10.1016/j.lungcan.2010.02.004
• 发表时间: 2010-11-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Roy, Badal C.;Kohno, Takashi;Yokota, Jun
• 通讯作者: Yokota, Jun

Involvement of LKB1 in Epithelial-Mesenchymal Transition(EMT)in Human Lung Cancer

LKB1 参与人肺癌上皮间质转化 (EMT)

• 发表时间: 2009
• 作者: Jiang X;Austin PF;Niederhoff RA;Manson SR;Riehm JJ;Cook BL;Pengue G;Chitaley K;Nakayama K;Nakayama KI;Weintraub SJ.;森口徹生
• 通讯作者: 森口徹生

LKB1 inactivation triggers EMT through the induction of transcriptional repressor ZEB1 in human lung cancer

LKB1 失活通过诱导人类肺癌中的转录抑制因子 ZEB1 触发 EMT

• 发表时间: 2008
• 作者: 森口徹生;et al
• 通讯作者: et al

KRAS/LKB1変異による肺腺がん細胞のEMTとがん幹細胞マーカーの発現誘導

肺腺癌细胞的 EMT 及 KRAS/LKB1 突变诱导癌症干细胞标志物表达

• 发表时间: 2009
• 作者: Susaki E;Nakayama K;Yamasaki L;Nakayama KI.;森口徹生
• 通讯作者: 森口徹生