Study of encephalopathy inducing constituent in Pleurocybella porrigens

侧扁菇脑病诱发成分的研究

• 批准号: 20590004
• 负责人: OHTA Tomihisa
• 金额: $ 3万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590004/
• 关键词: 生物活性物質; スギヒラタケ; 脳症; ペプチドグリカン; スフィンゴ糖脂質; 担子菌

This study was focused on the supposition that Angel Wing (Pleurocybella porrigens) brain disorder was based on plural toxic causes. The refinement and the structural analysis of the peptidyl polysialic analogues having internal organs disorder characteristics and inflammatory nature showed that N-glycolyl neuraminic acid (NeuGc) indicating the antigenicity was specifically included in the glycoprotein of the Angel Wing. On the other hand, the structure of sphingoglycolipid A was determined and synthesized. Sphingoglycolipid A was presumed on impaired characteristics to the nervous system and intestinal epithelia.

本研究的重点是假设天使翅(Pleurocybella Porrigens)脑功能障碍是基于多种中毒原因。对具有内脏器官紊乱特性和炎症性的多肽基多唾液酸类似物的提纯和结构分析表明，天使翼的糖蛋白中特异性地含有抗原性的N-羟基神经氨酸(NeuGc)。另一方面，确定并合成了狮身人掌糖脂A的结构。神经鞘糖脂A被认为是神经系统和肠道上皮受损的特征。

项目成果

N-glycoryl neuraminic acid from edible/toxic mushroom pleurocy bella porrigens

来自食用/有毒蘑菇侧耳菌的 N-甘酰神经氨酸

• 发表时间: 2008
• 作者: J. Date;T. Takata;T. Tatsuno;Y. Ishigaki. F. Takano;T. Ohta
• 通讯作者: T. Ohta

Isolation of N-acetyhlneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens

从侧扁藻中分离 N-乙酰神经氨酸和 N-乙醇酰神经氨酸

• 发表时间: 2009
• 期刊: J.Health Science 55(3)
• 作者: T.Takata;T.Hasegawa;T.Tatsuno;J.Date;Y.Ishigaki;Y.Nakamura;N.Tomosugid;F.Takano;T.Ohta
• 通讯作者: T.Ohta

N-glycoryl neuraminic acid from edible/toxic mushroom Pleurocybella porrigens

食用/有毒蘑菇 Pleurocybella porrigens 中的 N-甘酰神经氨酸

• 发表时间: 2008
• 作者: J.Date;T.Takata;T.Tatsuno;Y.Ishigaki;F.Takano;T.Ohta
• 通讯作者: T.Ohta