Programmed cell death in neuronal cells induced by a trienoic fatty acid

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In order to clarify the mechanisms by which eleostearic acid (ESA) induces neuronal cell death, cell viability assay was performed using various inhibitors and RNA interference for apoptosis-related molecules such as MEK, PARP-1, AIE ESA induces apoptotic cell death morphologically. However, activation of caspase and PARP-1, and DNA damage were not observed. AIF migrates from mitochondria to the nucleus upon ESA stimulation. ERK is also phosphorylated by ESA. The cell death is blocked by the inhibition of MEK and antioxidant tocopherol.