Study of the mechanizum of acute encephalopathy caused by cyanogenic mushroom

氰蘑菇引起急性脑病机制的研究

• 批准号: 23590848
• 负责人: GONMORI Kunio
• 金额: $ 3.66万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590848/
• 关键词: きのこ中毒; 急性脳症; 青酸; スギヒラタケ; 培養; 質量分析; 代謝

In autumn 2004, 59 cases of acute encephalopathy were reported across 9 prefectures in Japan.We concluded that encephalopathy experienced caused by was the cyanogenic mushroom.We study the mechanism of the acute encephalopathy by cyanogenic mushroom, Pleurocybella porrigens. For three years from 2011, we collect the mushrooms at a same point.But the occureence of mushroom is not enough except 2012 by unseasonable weather.It is difficult to study with natural materials is affected by the environment such as weather. We tried to artificial cultivation the Pleurocybella porrigens.

2004年秋季，日本9个都道府县共报告了59例急性脑病病例，我们认为脑病是由致氰蘑菇引起的，我们研究了致氰蘑菇-从2011年开始连续三年在同一地点采集蘑菇，但除2012年因气候异常，蘑菇的发生量不高外，其他年份都不多，受气候等环境因素的影响，用天然材料进行研究比较困难。我们尝试了人工培养多孔侧弯藻。

项目成果

MALDI-TOF mass spectrometric analysis of α-amanitin, β-amanitin, and phalloidin in urine

• DOI: 10.1007/s11419-012-0145-6
• 发表时间: 2012-06
• 期刊: Forensic Toxicology
• 影响因子: 2.2
• 作者: K. Gonmori;K. Minakata;Masako Suzuki;I. Yamagishi;H. Nozawa;Koutaro Hasegawa;Amin Wurita;Kanako Watanabe;O. Suzuki

A Sunsitive and fully automated method for GC-MS analysis of volatile organic cmpounds in whole blood using large volumes of headspace vapor

使用大量顶空蒸气对全血中挥发性有机化合物进行 GC-MS 分析的灵敏全自动方法

• 发表时间: 2012
• 作者: Koutaro Hasegawa;Amin Wurita;Kunio Gonmori;Hideki Nozawa;Itaru Yamagishi;Kayoko Minakata;Kanako Watanabe;Osamu Suzuki
• 通讯作者: Osamu Suzuki

A new approach in tandem mass spectrometric simultaneous determination of perchlorate, thiocyanate, and iodide using their ternary complexes with tris (1,10-phenanthroline) iron(II) chelate

利用三(1,10-菲咯啉)铁(II)螯合物的三元络合物串联质谱同时测定高氯酸盐、硫氰酸盐和碘化物的新方法

• DOI: 10.1007/s11419-012-0140-y
• 发表时间: 2012
• 期刊: Forensic Toxicology
• 影响因子: 2.2
• 作者: Kayoko Minakata;Hideki Nozawa
• 通讯作者: Hideki Nozawa

Analysis of ibotenic acid and muscimol in Amanita mushrooms by hydrophilic interaction LC-MS-MS with solid-phase extraction.

通过亲水相互作用 LC-MS-MS 固相萃取分析鹅膏菌中的鹅膏菌酸和蝇蕈醇。

• 发表时间: 2012
• 作者: Kunio Gonmori;Koutaro Hasegawa;Hiroki Fujita;Yoshito Kamijo;Hideki Nozawa;Itaru Yamagishi;Kayoko Minakata;Kanako Watanabe;Osamu Suzuki
• 通讯作者: Osamu Suzuki