Organelle selective targeting of ABC subfamily D proteins and molecular mechanisms of their functions on the membranes

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We found that the hydrophobic properties of NH_2-terminal cytosolic region of ABC subfamily D proteins determine their subcellular localization. ABC proteins (ABCD1～3) with the NH_2-terminal hydrophobic region are targeted to peroxisomes through the interaction of ABCD1～3 to Pex19p and Pex3p. On the other hand, ABCD4 without the hydrophobic region is targeted to endoplasmic reticulum. Concerning function of ABC subfamily D proteins, ABCD1～3 are suggested to be involved in transport to acyl-CoA and ABCD4 is involved in heme metabolism.