Elucidation of signal transduction systems which are regulated by BHD tumor suppressor protein

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It was found that the suppression of BHD (Birt-Hogg-Dube syndrome gene) tumor suppressor protein expression reduced the amount of mTOR complex (mTORC1) and induces cyclin D1 protein level. It is suggested that the BHD mutation induces dysregulation of a signal transduction system regulating cyclin D1 mRNA level and leads to tumorigenesis through aberrant cell cycle. This regulatory system for cyclin D1 expression may be a novel target to develop therapeutic drug for BHD and other tumor predisposing diseases.