A study for the role of ADAMs in the relationship between hepatocellular carcinoma and hepatic stellate cells.

ADAMs在肝细胞癌与肝星状细胞关系中的作用研究。

• 批准号: 20590371
• 负责人: KOTANI Koji
• 金额: $ 3.08万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590371/
• 关键词: 肝; 星細胞; 間質; ADAM; 相互作用; 肝臓; 肝線維症; 肝星細胞; エピジェネティックス; 肝炎; 肝硬変

We have attempted to develop the model of relationship between hepatocellular carcinoma and hepatic stellate cells. For the purpose, we constructed two inducible clones (Tet-kADAM-HepG2 and Tet-kADAM-LI-90). However, both we failed to the cloning of both transfectans. We generated other clones using another system, co-culture markedly decrease tumor cell growth and invasion activity. Thus, the relationships between HSC and hepatocellular carcinoma might contribute to hepatocellular carcinoma development.

我们试图建立肝星状细胞与肝癌的关系模型。为此，我们构建了两个诱导克隆（Tet-kADAM-HepG2和Tet-kADAM-LI-90）。然而，我们都未能克隆出两个转染体。我们用另一种系统生成了其他克隆，共培养显著降低了肿瘤细胞的生长和侵袭活性。因此，HSC与肝细胞癌之间的关系可能有助于肝细胞癌的发展。

项目成果

Detection of human papillomavirus in a urothelial carcinoma mimicking urethral caruncle.

在模拟尿道肉阜的尿路上皮癌中检测人乳头瘤病毒。

• 发表时间: 2010
• 期刊: Int J Urol 17
• 作者: Y. Tatemichi;H. Oikawa;C. Maesawa;J. Ambo;M. Sato;H. Koike;T. Sata;T. Fujioka;T. Masuda
• 通讯作者: T. Masuda

Accumbens-Associated 1 Contributes to Cortactin Deacetylation and Augments the Migration of Melanoma Cells.

Accumbens-Associated 1 有助于 Cortactin 脱乙酰化并增强黑色素瘤细胞的迁移。

• 发表时间: 2011
• 期刊: J Invest Dermatol in press
• 作者: K. Tsunoda;H. Oikawa;H. Tada;Y. Tatemichi;S. Muraoka;S. Miura;M. Shibazaki;F. Maeda;K. Takahashi;T. Akasaka;T. Masuda;C. Maesawa;Nucleus
• 通讯作者: Nucleus

Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells.

表观遗传修饰与卵巢癌细胞中 III 类 β-微管蛋白 TUBB3 的异常表达有关。

• 发表时间: 2008
• 期刊: Int J Oncol 32
• 作者: Izutsu N;Maesawa C;Masuda T.;et al
• 通讯作者: et al

Association of the TNF-{alpha}-C-857T polymorphism with resistance to the cholesterol-lowering effect of HMG-CoA reductase inhibitors in type 2 diabetic subjects.

TNF-{α}-C-857T 多态性与 2 型糖尿病受试者对 HMG-CoA 还原酶抑制剂降胆固醇作用的抵抗力的关联。

• 发表时间: 2010
• 期刊: Diabetes Care 33
• 作者: T. Takahashi;K. Takahashi;M. Yamashina;C. Maesawa;T. Kajiwara;H. Taneichi;N. Takebe;Y. Kaneko;T. Masuda;J. Satoh
• 通讯作者: J. Satoh

Effect of atorvastatin on microRNA 221/222 expression in endothelial progenitor cells obtained from patients with coronary artery disease

• DOI: 10.1111/j.1365-2362.2009.02110.x
• 发表时间: 2009-05-01
• 期刊: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 5.5
• 作者: Minami, Y.;Satoh, M.;Nakamura, M.
• 通讯作者: Nakamura, M.