Molecular mechanisms of invasion and metastasis in bone and soft-tissue sarcomas.
Molecular mechanisms of invasion and metastasis in bone and soft-tissue sarcomas.
批准号:
20590375
负责人:
SAITO Tsuyoshi
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We identified EWS-WT1(KTS+) fusion gene as a novel therapeutic target in desmoplastic small round cell tumor. Furthermore, exogenous expression of EWS-WT1(KTS+) in HeLa cells resulted in the acquisition of epithelial characteristics as evidenced by E-cadherin and β-catenin expression. Identification of p53 mutation in giant-cell tumor of bone might be a molecular pathological marker for malignant transformation of this tumor.
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Claudin-1,Claudin-4,E-cadherin,β-cateninの発現低下は大腸癌における予後不良因子である
Claudin-1、Claudin-4、E-cadherin 和 β-catenin 表达降低是结直肠癌的不良预后因素
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松岡隆、三富弘之、齋藤剛, ら]
通讯作者:
ら
Desmoplastic small round cell tumor におけるFGFR4高発現の意義とFGFR4シグナルの治療標的としての可能性
FGFR4 高表达在促结缔组织增生性小圆细胞肿瘤中的意义以及 FGFR4 信号作为治疗靶点的可能性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[齋藤剛, ら]
通讯作者:
ら
デスモイド腫瘍におけるβ-catenin遺伝子異常のタイプと標的遺伝子の活性化能および細胞増殖能の比較検討
硬纤维瘤β-catenin基因异常类型、靶基因激活能力及细胞增殖能力的比较研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[齋藤剛, ら]
通讯作者:
ら
DOI:
10.1007/s10549-010-0896-x
发表时间:
2011-04-01
期刊:
BREAST CANCER RESEARCH AND TREATMENT
影响因子:
3.8
作者:
[Yokotsuka, Mayumi, Iwaya, Keiichi, Mukai, Kiyoshi]
通讯作者:
Mukai, Kiyoshi
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DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 23 条
Establishment of new diagnostic approach for the primary unknown metastatic bone tumor
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批准号:26670286
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2014
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负责人:SAITO Tsuyoshi
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依托单位:
Characteristic of children with developmental disabilities with respect to physical fitness and physiological stress.
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批准号:22700682
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.33万
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财政年份:2010
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负责人:SAITO Tsuyoshi
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New developing method of concrete members against sulfate attack with low shrinkage and chemical stability
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批准号:22760328
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2010
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负责人:SAITO Tsuyoshi
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依托单位:
Historical Anthropology on Emergence and Development of an Indigenous Movement in Morocco
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批准号:21720320
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.91万
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财政年份:2009
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负责人:SAITO Tsuyoshi
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依托单位:
Bistandar effect via gap junctional intercellular communication for gene-therapy in gynecologic cancers.
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批准号:21592141
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:SAITO Tsuyoshi
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依托单位:
Research for Mechanism of Connexin Dysfunction during Carcinogenesis of Edometrium
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批准号:14571575
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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负责人:SAITO Tsuyoshi
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依托单位:
Development Study of Dental Implant, -The Expanded Utility in Clinical Indication Using Porous-Coated Implant-
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批准号:11695094
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$2.5万
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财政年份:1999
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负责人:SAITO Tsuyoshi
-
依托单位:
Change of cell-cell adhesion and intercellular communication in functional and carcinogenic endometrium
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批准号:11671638
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:1999
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负责人:SAITO Tsuyoshi
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依托单位:
The Survey Study of the Incidence their Analysis in the Success Rate.
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批准号:10307048
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项目类别:Grant-in-Aid for Scientific Research (A).
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资助金额:$17.41万
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财政年份:1998
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负责人:SAITO Tsuyoshi
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依托单位:
THE DEVELOPMENT OF AN INSTRUMENT OF MEASURE PERIODONTAL TISSUE WITH DAMPED OSCILLATION OF TEETH
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批准号:07557123
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.16万
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财政年份:1995
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负责人:SAITO Tsuyoshi
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依托单位:
AN ANALITICAL EVALUATION OF PERIODONTAL TISSUE CHANGE WITH DAMPED OSCILLATION OF TEETH.
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批准号:04404074
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$14.08万
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财政年份:1992
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负责人:SAITO Tsuyoshi
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依托单位:
海外基金