Identification of IL-18-induced Tumor-Cell Migration Inhibitory Factor(s) and Elucidation of its Action Mechanism..
Identification of IL-18-induced Tumor-Cell Migration Inhibitory Factor(s) and Elucidation of its Action Mechanism..
批准号:
20590414
负责人:
YAMADA Naoko
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
关键词:
中文摘要
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英文摘要
IL-18 shows an anti-tumor action through activation of T cells and natural killer cells. We found another action of IL-18, i.e., the inhibition of metastasis by inducing the factor(s) in serum which suppresses the tumor cell mobility. In this study, we aimed to identify the tumor-cell migration inhibitory factor(s). We have revealed that IL-18 induces the factor(s) in not only serum but also the cell lysate of the liver and lung and that the factor(s) is a protein of molecular weight of less than 30,000 daltons. We have also found several candidates for the factor(s).
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Coperative Antitumor Effects by Combined Administration α-Galactosylceramide and Interleukin-18 on Pulmonary Metastasis of Malignant Melanoma Cells.
联合使用 α-半乳糖神经酰胺和白细胞介素 18 对恶性黑色素瘤细胞肺转移的协同抗肿瘤作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Naoko Yamada, et al.]
通讯作者:
et al.
Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.
IL12RB2 5 侧翼区域多态性对 NK 细胞和 T 细胞活性的差异影响。
DOI:
--
发表时间:
2008
期刊:
J Interferon Cytokine Res. 28(9)
影响因子:
--
作者:
[Ohyama H, Kato-Kogoe N, Nishimura F, Takeuchi-Hatanaka K, Matsushita S, Yamanegi K, Yamada N, Hata M, Nakasho K, Terada N]
通讯作者:
Terada N
Cooperative Antitumor Effects by Combined Administration α-Galactosylceramide and Interleukin-18 on Pulmonary Metastasis of Malignant Melanoma Cells.
联合使用 α-半乳糖神经酰胺和白细胞介素 18 对恶性黑色素瘤细胞肺转移的协同抗肿瘤作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Naoko Yamada, Shoji Nishio, Hideki Ohyama, Koji Yamanegi, Keiji Nakasho, Haruki Okamura, Nobuyuki Terada]
通讯作者:
Nobuyuki Terada
Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha- galactosylceramide and interleukin-18.
α-半乳糖神经酰胺和白细胞介素 18 联合给药可增强对恶性黑色素瘤细胞肺转移的抑制。
DOI:
--
发表时间:
2008
期刊:
Cancer Sci. 99(1)
影响因子:
--
作者:
[Nishio S, Yamada N, Ohyama H, Yamanegi K, Nakasho K, Hata M, Nakamura Y, Fukunaga S, Futani H, Yoshiya S, Ueda H, Taniguchi M, Okamura H, Terada N]
通讯作者:
Terada N
成長期と成熟期における生殖幹細胞の品質保証システムの質的変化
生殖干细胞生长和成熟阶段质量保证体系的质变
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[蓬田健太郎、藤本寿々、遠藤倫代、山本遥菜、山田直子, 等]
通讯作者:
等
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How the interview techniques and recording medium affect on 'fact-findings'
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批准号:19K01359
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2019
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负责人:YAMADA Naoko
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依托单位:
Identification and the elucidation of the mechanism of interleukin 18 induced metastasis inhibitory factor(s)
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批准号:23590480
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:YAMADA Naoko
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依托单位:
Intertwining Norms and Laws on Marriage in the Dutch East Indies
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批准号:21720259
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.66万
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财政年份:2009
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负责人:YAMADA Naoko
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依托单位:
海外基金