Identification of IL-18-induced Tumor-Cell Migration Inhibitory Factor(s) and Elucidation of its Action Mechanism..

IL-18诱导的肿瘤细胞迁移抑制因子的鉴定及其作用机制的阐明

• 批准号: 20590414
• 负责人: YAMADA Naoko
• 金额: $ 3万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590414/
• 关键词: 腫瘍; インターロイキン18; 転移; 骨肉腫

IL-18 shows an anti-tumor action through activation of T cells and natural killer cells. We found another action of IL-18, i.e., the inhibition of metastasis by inducing the factor(s) in serum which suppresses the tumor cell mobility. In this study, we aimed to identify the tumor-cell migration inhibitory factor(s). We have revealed that IL-18 induces the factor(s) in not only serum but also the cell lysate of the liver and lung and that the factor(s) is a protein of molecular weight of less than 30,000 daltons. We have also found several candidates for the factor(s).

IL-18通过激活T细胞和自然杀伤细胞发挥抗肿瘤作用。我们发现了IL-18的另一个作用，即通过诱导血清中抑制肿瘤细胞移动的因子来抑制肿瘤转移。在本研究中，我们旨在鉴定肿瘤细胞迁移抑制因子(s)。我们发现IL-18不仅在血清中，而且在肝和肺的细胞裂解液中也能诱导该因子，该因子是一种分子量小于30,000道尔顿的蛋白质。我们还发现了几个候选因子。

项目成果

Coperative Antitumor Effects by Combined Administration α-Galactosylceramide and Interleukin-18 on Pulmonary Metastasis of Malignant Melanoma Cells.

联合使用 α-半乳糖神经酰胺和白细胞介素 18 对恶性黑色素瘤细胞肺转移的协同抗肿瘤作用。

• 发表时间: 2009
• 作者: Naoko Yamada;et al.
• 通讯作者: et al.

Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK- and T-cell activity.

IL12RB2 5 侧翼区域多态性对 NK 细胞和 T 细胞活性的差异影响。

• 发表时间: 2008
• 期刊: J Interferon Cytokine Res. 28(9)
• 作者: Ohyama H;Kato-Kogoe N;Nishimura F;Takeuchi-Hatanaka K;Matsushita S;Yamanegi K;Yamada N;Hata M;Nakasho K;Terada N
• 通讯作者: Terada N

Cooperative Antitumor Effects by Combined Administration α-Galactosylceramide and Interleukin-18 on Pulmonary Metastasis of Malignant Melanoma Cells.

联合使用 α-半乳糖神经酰胺和白细胞介素 18 对恶性黑色素瘤细胞肺转移的协同抗肿瘤作用。

• 发表时间: 2009
• 作者: Naoko Yamada;Shoji Nishio;Hideki Ohyama;Koji Yamanegi;Keiji Nakasho;Haruki Okamura;Nobuyuki Terada
• 通讯作者: Nobuyuki Terada

Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha- galactosylceramide and interleukin-18.

α-半乳糖神经酰胺和白细胞介素 18 联合给药可增强对恶性黑色素瘤细胞肺转移的抑制。

• 发表时间: 2008
• 期刊: Cancer Sci. 99(1)
• 作者: Nishio S;Yamada N;Ohyama H;Yamanegi K;Nakasho K;Hata M;Nakamura Y;Fukunaga S;Futani H;Yoshiya S;Ueda H;Taniguchi M;Okamura H;Terada N
• 通讯作者: Terada N

成長期と成熟期における生殖幹細胞の品質保証システムの質的変化

生殖干细胞生长和成熟阶段质量保证体系的质变

• 发表时间: 2010
• 作者: 蓬田健太郎、藤本寿々、遠藤倫代、山本遥菜、山田直子;等
• 通讯作者: 等