Analysis of iron-acquire receptor protein of Vibrio parahaemolyticus and development of specific growth inhibitor

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Most microorganisms absolutely require iron to survive and grow. Vibrio parahaemolyticus produces siderophore, vibrioferrin(VF), under iron restriction conditions. Although VF is important for growth of V. parahaemolyticus, its role for the pathogenesis remains unknown. In this study, Drosophila melanogaster was used for a growth assay of V. parahaemolyticus deletion mutant which lacks VF producibility, as a infection model. These results indicated that iron acquisition by VF was very important for the growth in D. melanogaster, and affected its lethal activity.