Molecular study of anti-protective immune response upon malaria

我们观察到寄生虫非特异性 T 细胞在感染疟原虫后发生功能变化。在这项研究中，我们探讨了寄生虫非特异性 T 细胞功能变化的机制及其影响。首先，我们发现 T 细胞的功能变化与传统 T 细胞的激活途径不同。接下来，我们发现 T 细胞的功能变化受到另一种免疫反应的影响，例如对李斯特菌的保护和 DNFB 诱导的接触超敏反应。

We have observed the functional changes of parasite-nonspecific T cells upon infection with Plasmodium. In this study, we addressed about the mechanisms and its impact of functional changes of parasite-non-specific T cells. First we identified that the functional changes of T cells are distinguishable of the activation pathway of conventional T cells. Next we identified that functional changes of T cells are influenced with another immune responses such as protection against Listeria and DNFB-induced contact hypersensitivity reaction.