Molecular mechanisms of sublingual immunotherapy

舌下免疫治疗的分子机制

• 批准号: 20590502
• 负责人: HIROI Takachika
• 金额: $ 3万
• 依托单位: Tokyo Metropolitan Organization for Medical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590502/
• 关键词: 粘膜免疫; 舌下免疫療法; スギ花粉症; アレルギー; IgE; 免疫寛容; T細胞; 抗原提示細胞; 脱顆粒; 舌下減感作療法; Th2; IL-4; OVA

In this study, we comparatively examined the effect of SLIT on antigen-induced airway inflammation developed in bronchoalveolar and nasal cavities in mice. Massive infiltration of eosinophils as well as neutrophils into the bronchoalveolar cavity was induced by intratracheal OVA challenge. In the nasal cavity, eosinophil accumulation was occurred, though the number of neutrophils was not significantly changed, in response to nasal antigen challenge. These antigen-induced airway inflammatory responses, including increase in the number of eosinophils and/or neutrophils in the bronchoalveolar and nasal cavities were clearly suppressed by sublingual OVA administration. This animal model displaying differential inflammatory responses in the bronchoalveolar and nasal cavities may be useful to elucidate the efficacy and mechanisms of SLIT against various allergic diseases.

在这项研究中，我们对比研究了Sit对抗原诱导的小鼠支气管肺泡和鼻腔的呼吸道炎症的影响。气管内注射OVA可诱导嗜酸性粒细胞和中性粒细胞大量渗入支气管肺泡腔。在鼻腔内，嗜酸性粒细胞聚集，但中性粒细胞的数量没有明显变化，以响应鼻腔抗原攻击。这些抗原诱导的呼吸道炎症反应，包括支气管肺泡和鼻腔内嗜酸性粒细胞和/或中性粒细胞数量的增加，明显地被舌下注射OVA所抑制。该动物模型在支气管、肺泡和鼻腔表现出不同的炎症反应，可能有助于阐明Sit治疗各种变态反应性疾病的疗效和机制。

项目成果

ヒトT細胞のIL-4産生に対するC-terminal binding proteinの役割

C 端结合蛋白在人 T 细胞产生 IL-4 中的作用

• 发表时间: 2009
• 作者: 神沼修;北村紀子;本井祐二;北村ふじ子;宮武昌一郎;三好浩之;巽英樹;根本荘一;森晶夫;廣井隆親
• 通讯作者: 廣井隆親

Rice seed ER-derived protein body as an efficient delivery vehicle for oral tolerogenic peptides

• DOI: 10.1016/j.peptides.2010.04.032
• 发表时间: 2010-08-01
• 期刊: PEPTIDES
• 影响因子: 3
• 作者: Takagi, Hidenori;Hiroi, Takachika;Takaiwa, Fumio
• 通讯作者: Takaiwa, Fumio

T. T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells

T. T-box 21 转录因子导致人外周 CD4 T 细胞 TH2 分化扭曲

• 发表时间: 2009
• 期刊: J Allergy Clin Immunol 123
• 作者: Kaminuma O.;Kitamura F.;Miyatake S.;Yamaoka K.;Miyoshi H;Inokuma S;Tatsumi H;Nemoto S;Kitamura N;Mori A;Hiroi
• 通讯作者: Hiroi

Selective Down-Regulation of Th2 Cytokines by C-Terminal Binding Protein 2 in Human T Cells

• DOI: 10.1159/000312121
• 发表时间: 2010-06
• 期刊: International Archives of Allergy and Immunology
• 影响因子: 2.8
• 作者: F. Kitamura;N. Kitamura;A. Mori;H. Tatsumi;Soichi Nemoto;H. Miyoshi;S. Miyatake;T. Hiroi;O. Kaminuma

T細胞依存性の好酸球性気道炎症に対するCCR4拮抗薬の作用

CCR4 拮抗剂对 T 细胞依赖性嗜酸性粒细胞气道炎症的影响

• 发表时间: 2009
• 作者: 神沼修;大友隆之;森晶夫;長久保大輔;稗島州雄;義江修;鈴木一矢;廣井隆親
• 通讯作者: 廣井隆親