The role of micro RNA and methylated gene in multistep genesis and prognosis of multiple myeloma
The role of micro RNA and methylated gene in multistep genesis and prognosis of multiple myeloma
批准号:
20590556
负责人:
HANDA Hiroshi
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We detected methylated WWOX promoter in myeloma cell lines, myeloma patients but not in MGUS patients. The aberrant transcript of WWOX mRNA was detected in myeloma patients, MGUS and cell lines. The expression level of micro-RNA miR15a 15b, 16 were very low or lacked in purified plasma cells in some patients. MiR 15a, 15b, 16 levels were lower in plasma cells of MM than those of MGUS. On the contrary, Dnmts and Mcl-1 levels were higher in plasma cells of MM than those of MGUS.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Common fragile site gene FHIT (fragile histidine triad gene) and WWOX (WW domain containing oxidoreductase) expression are frequently altered in multiple myeloma.
常见脆弱位点基因 FHIT(脆弱组氨酸三联体基因)和 WWOX(含氧化还原酶的 WW 结构域)表达在多发性骨髓瘤中经常发生改变。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui, 半田寛]
通讯作者:
半田寛
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Construction of Artificial Capsule by Using Novel Bio- Materials
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Interaction of human Spt4 Spt5 with transcription machinery
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Investigation on the Interaction between the Molecules Constituting Viruses and Application to Gene Therapy
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Function of basal transcription factor TFIIA as coactivator
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依托单位:
海外基金