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The role of micro RNA and methylated gene in multistep genesis and prognosis of multiple myeloma

The role of micro RNA and methylated gene in multistep genesis and prognosis of multiple myeloma
微小RNA和甲基化基因在多发性骨髓瘤多步发生和预后中的作用
批准号:
20590556
负责人:
HANDA Hiroshi
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We detected methylated WWOX promoter in myeloma cell lines, myeloma patients but not in MGUS patients. The aberrant transcript of WWOX mRNA was detected in myeloma patients, MGUS and cell lines. The expression level of micro-RNA miR15a 15b, 16 were very low or lacked in purified plasma cells in some patients. MiR 15a, 15b, 16 levels were lower in plasma cells of MM than those of MGUS. On the contrary, Dnmts and Mcl-1 levels were higher in plasma cells of MM than those of MGUS.
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Common fragile site gene FHIT (fragile histidine triad gene) and WWOX (WW domain containing oxidoreductase) expression are frequently altered in multiple myeloma.
常见脆弱位点基因 FHIT(脆弱组氨酸三联体基因)和 WWOX(含氧化还原酶的 WW 结构域)表达在多发性骨髓瘤中经常发生改变。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui, 半田寛]
通讯作者: 半田寛
Search for novel modulators of cereblon, the target of thalidomide that regulates neural stem cell proliferation and deifferentiation
  • 批准号:
    17H06112
  • 项目类别:
    Grant-in-Aid for Scientific Research (S)
  • 资助金额:
    $115.9万
  • 财政年份:
    2017
  • 负责人:
    HANDA Hiroshi
  • 依托单位:
Exhaled breath analysis for lung cancer detection using ion mobility spectrometry
  • 批准号:
    24800068
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
  • 资助金额:
    $1.0万
  • 财政年份:
    2012
  • 负责人:
    HANDA Hiroshi
  • 依托单位:
Development of high-performance nano-carrier for next generation medicine
  • 批准号:
    21241029
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $29.95万
  • 财政年份:
    2009
  • 负责人:
    HANDA Hiroshi
  • 依托单位:
Development and application of functionalized nanocapsules
  • 批准号:
    19201024
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $25.21万
  • 财政年份:
    2007
  • 负责人:
    HANDA Hiroshi
  • 依托单位:
海外基金