Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican Children

多米尼加儿童幽门螺杆菌感染和慢性萎缩性胃炎的患病率

• 批准号: 20590606
• 负责人: AOKI Kazuo
• 金额: $ 3万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590606/
• 关键词: ヘリコバクター・ピロリ(H.pylori)感染; 胃がん; 慢性萎縮性胃炎; ドミニカ共和国; ペプシノゲン; ガストリン; CagA抗体; 疫学; ヘリコバクタ・ピロリ感染; 小児; CagA; 生活習慣; 生活環境; Cag A

TITLE : Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican ChildrenPURPOSE : To show the prevalence of H. pylori infection and chronic atrophic gastritis (CAG) and the positivity of CagA antibody to H. pylori in the Dominican children, and to clarify the several factors that related to H. pylori infection and CAG by multivariate analysis.METHODS : One thousand and thirty one subjects who have given us the informed consent in writing were volunteers from children of the nursery school, a kindergarten, a primary school, and a junior high school in the Dominican Republic. Each individual underwent a health checkup and blood sampling for measurement of serum pepsinogen I and II, pepsinogen I/II ratio, serum gastrin, H. pylori antibodies, and CagA antibody to H. pylori, and responded to a questionnaire on upper digestive tract diseases.RESULTS : The prevalence of H. pylori infection (0.000-0.467) and CAG (0.000-0.158) varied by age and sex. The positivity of C … More agA antibody to H. pylori for boys and girls increased by advancing age in the Dominican children.To show the factors related to be H. pylori infection was done the stepwise regression analysis using forward likelihood procedure and choosing H. pylori infection as the dependent variable. The model included twenty-five independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender and age, and subjects examined data ; serum gastrin level. In this final step of the logistic regression model, of the subjects without H. pylori infection, 93.5% were correctly classified. Of the subjects with H. pylori infection, 27.7% were correctly classified. Overall, 75.6% of all subjects were correctly classified. The odds ratio of H. pylori infection in male subjects was 1.465 to female subjects. The odds ratio of H. pylori infection was 1.326 when age of the subject increase one year old. The odds ratio of H. pylori infection was 1.185 when numbers of children who live together increase one person. The odds ratio of H. pylori infection in subjects with diarrhea as subjective symptom was 1.567 to those without diarrhea. The odds ratio of H. pylori infection was 1.008 when serum gastrin level of the subject increases 1 pg/ml.To clarify the factors related to be chronic atrophic gastritis (CAG) was done the stepwise regression analysis using forward likelihood procedure and choosing chronic atrophic gastritis (CAG) as the dependent variable. The model included nine independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender, and age, subjects examined data; serum gastrin level, H. pylori infection, and antibody of CagA to H. pylori). In this final step of the logistic regression model, of the subjects without CAG, 99.0% were correctly classified. Of the subjects with CAG, 18.5% were correctly classified. Overall, 88.0% of all subjects were correctly classified. The odds ratio of CAG was 1.006 when serum gastrin level of the subject increased 1 pg/ml. The odds ratio of CAG in subjects with antibody of CagA to H. pylori infection was 2.090 to those without antibody of CagA. The odds ratio of CAG in subjects with H. pylori infection was 2.738 to those without H. pylori infection.The Cross tabulation by gender between H. pylori infection and antibody of CagA to H. pylori showed it that the positivity of CagA antibody has not seen significant differences between boys and girls. However, the positivity of CagA antibody was about 20 % by our CagA measurement kit in subjects1 who have had no H. pylori infection.CONCLUSIONS :Our results indicated that serum gastrin, CagA antibody to H. pylori, and H. pylori infection are a good marker of CAG even in children. To clarify the relationship between the positivity of CagA antibody to H. pylori and chronic atrophic gastritis need further study. Less

TITLE : 多米尼加儿童 H. pylori 感染和慢性萎缩性胃炎的患病率目的 : 显示多米尼加儿童 H. pylori 感染和慢性萎缩性胃炎 (CAG) 的患病率以及 H. pylori CagA 抗体的阳性情况，并通过多变量阐明与 H. pylori 感染和慢性萎缩性胃炎 (CAG) 相关的几个因素 方法：1031名书面知情同意书的受试者是来自多米尼加共和国托儿所、幼儿园、小学和初中的孩子们的志愿者。每位受试者均进行健康体检、抽血检测血清胃蛋白酶原I、II、胃蛋白酶原I/II比值、血清胃泌素、幽门螺杆菌抗体、幽门螺杆菌CagA抗体，并填写上消化道疾病调查问卷。 结果：幽门螺杆菌感染患病率 (0.000-0.467) 和 CAG (0.000-0.158) 因年龄和性别而异。多米尼加儿童中男孩和女孩的幽门螺杆菌 agA 抗体阳性率随着年龄的增长而增加。为了显示与幽门螺杆菌感染相关的因素，使用前向似然法进行逐步回归分析，并选择幽门螺杆菌感染作为因变量。该模型包括25个自变量（胃肠道疾病相关的主观症状、既往史和家族史、环境、生活方式、性别和年龄以及受试者检查数据；血清胃泌素水平。在逻辑回归模型的最后一步中，在没有感染幽门螺杆菌的受试者中，93.5%被正确分类。在感染幽门螺杆菌的受试者中，27.7%被正确分类。 总体而言，75.6% 的受试者被正确分类。男性受试者与女性受试者相比，幽门螺杆菌感染的优势比为 1.465。当受试者年龄增加一岁时，幽门螺杆菌感染的优势比为1.326。当一起居住的儿童数量增加1人时，幽门螺杆菌感染的优势比为1.185。幽门螺杆菌感染的优势比 以腹泻为主观症状的受试者为无腹泻受试者的 1.567。当受试者血清胃泌素水平增加1 pg/ml时，幽门螺杆菌感染的优势比为1.008。为了澄清与慢性萎缩性胃炎（CAG）相关的因素，使用前向似然法进行逐步回归分析，并选择慢性萎缩性胃炎（CAG）作为 因变量。该模型包括9个自变量（胃肠道疾病相关主观症状、既往史和家族史、环境、生活方式、性别和年龄、受试者检查数据；血清胃泌素水平、幽门螺杆菌感染和幽门螺杆菌CagA抗体）。在逻辑回归模型的最后一步中，对于没有 CAG 的受试者，99.0% 的分类正确。 在患有 CAG 的受试者中，18.5% 的分类正确。总体而言，88.0% 的受试者被正确分类。当受试者血清胃泌素水平增加1 pg/ml时，CAG的优势比为1.006。具有CagA幽门螺杆菌感染抗体的受试者与没有CagA抗体的受试者相比，CAG的优势比为2.090。 CAG 的优势比 幽门螺杆菌感染者与未感染者的比例为2.738。幽门螺杆菌感染者与幽门螺杆菌CagA抗体按性别进行交叉表显示，男女生CagA抗体阳性率无显着差异。然而，通过我们的 CagA 测量试剂盒，在曾经患有 没有幽门螺杆菌感染。结论：我们的结果表明，即使在儿童中，血清胃泌素、幽门螺杆菌 CagA 抗体和幽门螺杆菌感染也是 CAG 的良好标志。阐明H. pylori CagA抗体阳性与慢性萎缩性胃炎的关系还需进一步研究。少

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• 发表时间: 2010
• 期刊: 九州農村医学会雑誌 19&20
• 作者: 佐藤素子;塩飽邦憲;Nishino Hoyoku;青木一雄
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Long-term administration of sterigumatocystin with drinking water in Helicobacter pylori-infected aged Mongolian gerbils enhances carcinogenesis in the gastric mucosa.

在感染幽门螺杆菌的老年蒙古沙鼠中长期用饮用水给予杂斑半胱氨酸会增强胃粘膜的癌变。

• 发表时间: 2009
• 期刊: Journal of Physical Fitness, Nutrition and Immunology 19
• 作者: Kusunoki M;Misumi J;Aoki K;Shimada T;Matsuo N;Sumiyoshi H;Ebine N;Yamaguchi T;Okamoto A;Yoshioka H.
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• 发表时间: 2008
• 作者: 明石光伸;上田厚;青木一雄;他,編著
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Helicobacter pylori infection and chronic atrophic gastritis in East Asia, the tropics, and the subtropics～A clue to solve "Asian paradox","African enigma" and "Caribbean wonder" based on the field studies in Japan, China

东亚、热带、亚热带的幽门螺杆菌感染与慢性萎缩性胃炎～基于日本、中国的实地调查，解决“亚洲悖论”、“非洲之谜”、“加勒比奇迹”的线索

• 发表时间: 2008
• 期刊: Tanzania, and the Dominican Republic～Ryukyu Medical Journal 27
• 作者: Yamasaki M;Anuurad E;Schachter N;Berglund L;Aoki K.
• 通讯作者: Aoki K.

Helicobacter pylori infection and chronic atrophic gastritis in East Asia, the tropics, and the subtropics〜A clue to solve “Asian paradox", “African enigma" and

东亚、热带、亚热带的幽门螺杆菌感染与慢性萎缩性胃炎〜解开“亚洲悖论”、“非洲之谜”的线索

• 发表时间: 2008
• 期刊: Ryukyu Medical Journal 27
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