Effect on life style to Helicobacter pylori infection and/or chronic atrophic gastritis in the tropics

对多米尼加共和国478名居民进行上消化道疾病的详细问卷调查，然后进行血清胃蛋白酶原筛查慢性萎缩性胃炎、血清胃泌素和H.幽门。在成人受试者中，H. pylori感染率男女分别为61.1%和64.7%。慢性萎缩性胃炎的患病率男性为16.7%，女性为11.8%。H. pylori感染和慢性萎缩性胃炎。虽然H.吸烟者与非吸烟者之间H.吸烟女性的幽门螺杆菌感染率（91.7%）高于非吸烟女性（60.3%）。多米尼加共和国15岁以下人群幽门螺杆菌感染率随年龄增长而增高，0-5岁、5-10岁和10-15岁年龄组分别为32.3%、45.1%和56.0%。pylori感染或慢性萎缩性胃炎。在logistic回归模型中选择了三个显著的自变量（性别、年龄和血清胃泌素浓度）。H.男性pylori感染率是女性的0.595倍。H. pylori感染率随年龄增长每年增加3.2%，血清胃泌素水平每年增加0.3%/1 pg/ml。同样，在使用logistic回归分析估计某些因素与慢性萎缩性胃炎的比值比后，在该模型中仅选择一个显著的自变量（血清胃泌素浓度）。血清胃泌素水平升高1 pg/ml，慢性萎缩性胃炎的优势比增加0.9%。

Commurity-based study in which 478 inhabitants of the Dominican Republic answered detailed questionnaires on upper digestive tract diseases, and then underwent screening for chronic atrophic gastritis by serum pepsinogen and testing for serum gastrin and antibody to H. pylori. In adult's subjects, the prevalences of H. pylori infection were 61.1% and 64.7% for males and females, respectively. Also, the prevalences of chronic atrophic gastritis were 16.7% and 11.8% for males and females, respectively. There were no sex differences in the prevalences of H. pylori infection and those of chronic atrophic gastritis. Although no significant difference was seen in the prevalence of H. pylori infection between smoker and non smoker males, that of H. pylori in smoker females(91.7%) was higher than that in non-smoker females(60.3%).On the other hand, the prevalence of H. pylori increased with advancing age in the subjects less than 15 years old in the Dominican Republic, and they were 32.3%, 45.1%, and 56.0% in the age group of 0-5, 5-10, and 10-15 years of age.Logistic regression analysis with stepwise method using forward likelihood procedure was conducted to assess the odds ratio of related factors to H. pylori infection or chronic atrophic gastritis for all 478 subjects. Three significant independent variables (sex, age, and serum gastrin concentration) were selected in the logistic regression model. The odds ratio of H. pylori infection in males was 0.595 times that in females. The odds ratio of H. pylori increased 3.2%/year in advancing age and 0.3%/1pg/ml increase in serum gastrin level. In the same way, after using logistic regression analysis to estimate the odds ratio of some factors to chronic atrophic gastritis, only one significant independent variable (serum gastrin concentration) was selected in this model. The odds ratio of chronic atrophic gastritis increased 0.9%/1pg/ml increase in serum gastrin level.