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Effect on life style to Helicobacter pylori infection and/or chronic atrophic gastritis in the tropics

热带地区生活方式对幽门螺杆菌感染和/或慢性萎缩性胃炎的影响

基本信息

批准号：
17590518
负责人：
AOKI Kazuo
金额：
$ 2.24万
依托单位：
Oita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

Commurity-based study in which 478 inhabitants of the Dominican Republic answered detailed questionnaires on upper digestive tract diseases, and then underwent screening for chronic atrophic gastritis by serum pepsinogen and testing for serum gastrin and antibody to H. pylori. In adult's subjects, the prevalences of H. pylori infection were 61.1% and 64.7% for males and females, respectively. Also, the prevalences of chronic atrophic gastritis were 16.7% and 11.8% for males and females, respectively. There were no sex differences in the prevalences of H. pylori infection and those of chronic atrophic gastritis. Although no significant difference was seen in the prevalence of H. pylori infection between smoker and non smoker males, that of H. pylori in smoker females(91.7%) was higher than that in non-smoker females(60.3%).On the other hand, the prevalence of H. pylori increased with advancing age in the subjects less than 15 years old in the Dominican Republic, and they were 32.3%, 45.1%, and 56.0% in the age group of 0-5, 5-10, and 10-15 years of age.Logistic regression analysis with stepwise method using forward likelihood procedure was conducted to assess the odds ratio of related factors to H. pylori infection or chronic atrophic gastritis for all 478 subjects. Three significant independent variables (sex, age, and serum gastrin concentration) were selected in the logistic regression model. The odds ratio of H. pylori infection in males was 0.595 times that in females. The odds ratio of H. pylori increased 3.2%/year in advancing age and 0.3%/1pg/ml increase in serum gastrin level. In the same way, after using logistic regression analysis to estimate the odds ratio of some factors to chronic atrophic gastritis, only one significant independent variable (serum gastrin concentration) was selected in this model. The odds ratio of chronic atrophic gastritis increased 0.9%/1pg/ml increase in serum gastrin level.

以社区为基础的研究，478名多米尼加共和国居民回答了有关上消化道疾病的详细调查问卷，然后通过血清胃蛋白酶原筛查慢性萎缩性胃炎，并检测血清胃泌素和幽门螺杆菌抗体。在成人受试者中，男性和女性幽门螺杆菌感染率分别为61.1%和64.7%。此外，男性和女性慢性萎缩性胃炎的患病率分别为16.7%和11.8%。幽门螺杆菌感染和慢性萎缩性胃炎的患病率没有性别差异。虽然吸烟者与不吸烟男性的幽门螺杆菌感染率没有显着差异，但吸烟女性的幽门螺杆菌感染率(91.7%)高于不吸烟女性(60.3%)。另一方面，多米尼加共和国15岁以下受试者中幽门螺杆菌感染率随着年龄的增长而增加，为32.3%， 0-5岁、5-10岁和10-15岁年龄组中分别为45.1%和56.0%。采用正向似然程序逐步法进行Logistic回归分析，以评估所有478名受试者中幽门螺杆菌感染或慢性萎缩性胃炎相关因素的比值比。在逻辑回归模型中选择了三个显着的自变量（性别、年龄和血清胃泌素浓度）。男性感染幽门螺杆菌的比值比是女性的0.595倍。随着年龄的增长，幽门螺杆菌的优势比每年增加 3.2%，血清胃泌素水平增加 0.3%/1pg/ml。同样，在使用逻辑回归分析估计某些因素与慢性萎缩性胃炎的比值比后，该模型仅选择一个显着的自变量（血清胃泌素浓度）。血清胃泌素水平每增加1pg/ml，慢性萎缩性胃炎的比值比增加0.9%。