Gene-gene and gene-environment interactions between polymorphisms in alcohol-metabolizing enzyme genes and the risk of gastric cancer

酒精代谢酶基因多态性与胃癌风险之间的基因-基因和基因-环境相互作用

• 批准号: 20590624
• 负责人: HIRAKI Akio
• 金额: $ 3.08万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590624/
• 关键词: 胃がんリスク; 胃がん; 罹患リスク

H.pylori seropositivity in the controls was not significantly associated with the AICDA 7888 C/T genotypes. Among the H. pylori seropositive control subjects, the age and sex-adjusted ORs of atrophic gastritis were not statistically significant. The age- and sex-adjusted ORs of gastric cancer relative to atrophic gastritis were also not statistically significant. The hypothetical association of the AICDA 7888 C/T polymorphism with the risk of gastric cancer or gastric atrophy was not shown in this study.

对照组幽门螺杆菌抗体阳性与AICDA 7888C/T基因型无显著相关性。在幽门螺杆菌阳性对照组中，年龄和性别调整后的萎缩性胃炎的OR值无统计学意义。年龄和性别调整后的胃癌相对于萎缩性胃炎的OR值也没有统计学意义。本研究未显示AICDA 7888 C/T多态与胃癌或胃萎缩风险的假设关联。

项目成果

Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese

• DOI: 10.1002/ijc.24519
• 发表时间: 2009-10-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Matsuo, Keitaro;Tajima, Kazuo;Tanaka, Hideo
• 通讯作者: Tanaka, Hideo

Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk

• DOI: 10.1158/1055-9965.epi-08-0470
• 发表时间: 2008-10-01
• 期刊: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
• 影响因子: 3.8
• 作者: Suzuki, Takeshi;Matsuo, Keitaro;Tanaka, Hideo
• 通讯作者: Tanaka, Hideo

Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach

• DOI: 10.1158/1055-9965.epi-08-0462
• 发表时间: 2009-01-01
• 期刊: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
• 影响因子: 3.8
• 作者: Boccia, Stefania;Hashibe, Mia;Boffetta, Paolo
• 通讯作者: Boffetta, Paolo

No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.

日本人的 AICDA 7888 C/T 多态性、幽门螺杆菌血清阳性与萎缩性胃炎和胃癌的风险之间没有关联。

• 发表时间: 2010
• 期刊: Gastric Cancer. 13(1)
• 作者: Hishida A;Matsuo K;Goto Y;Mitsuda Y;Hiraki A;Naito M;Wakai K;Tajima K;Hamajima N.
• 通讯作者: Hamajima N.

Toll-Like Receptor 4+3725 G/C Polymorphism, Helicobacter pylori Seropositivity, and the Risk of Gastric Atrophy and Gastric Cancer in Japanese

• DOI: 10.1111/j.1523-5378.2009.00659.x
• 发表时间: 2009-02-01
• 期刊: HELICOBACTER
• 影响因子: 4.4
• 作者: Hishida, Asahi;Matsuo, Keitaro;Hamajima, Nobuyuki
• 通讯作者: Hamajima, Nobuyuki