Preventive effect of histidine and proline on obesity and anorexia through the control of appetite.

组氨酸和脯氨酸通过控制食欲对肥胖和厌食症具有预防作用。

• 批准号: 20590666
• 负责人: NAKAJIMA Shigeru
• 金额: $ 2.83万
• 依托单位: Bunkyo University Women's College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590666/
• 关键词: 肥満; 拒食; ヒスチジン; プロリン

The aim of this study is to investigate the influence of proline for the preventive effect of histidine on obesity. The preventive effect of histidine on obesity seemed to decrease by proline. Because, the meal consist of high histidine/proline ratio seemed to be useful to prevent and dissolve obesity. In the case of aneroxia, body protein change to amino acids to make energy. From this result, histidine in blood seemed to increase and hitamine neuron is activated extraordinary. Because, the meal consist of low histidine/protein ratio seemed to increase the appetite.

本研究旨在探讨脯氨酸对组氨酸预防肥胖作用的影响。组氨酸对肥胖的预防作用似乎被脯氨酸降低了。因为，高组氨酸/脯氨酸比例的膳食似乎有助于预防和化解肥胖。在缺氧的情况下，体内的蛋白质变成氨基酸来制造能量。从这个结果来看，血液中的组氨酸似乎增加了，hitamine神经元被异常激活。因为，低组氨酸/蛋白质比例的膳食似乎增加了食欲。

项目成果

ヒスチジン摂取ラットの血清、脳におけるDEDCとCu投与による過酸化脂質濃度の変化

摄入组氨酸的大鼠血清和脑中 DEDC 和 Cu 引起的脂质过氧化物浓度的变化

• 发表时间: 2009
• 作者: 井上節子;中島滋
• 通讯作者: 中島滋

Seafood Quality, Safety, and Health(「Suppressive effects of marine foods intake on obesity and life style related diseases」)

海鲜质量、安全和健康（“海洋食品摄入对肥胖和生活方式相关疾病的抑制作用”）

• 发表时间: 2010
• 作者: 塚正彦;大島徹;大石和佳;Shigeru Nakajima
• 通讯作者: Shigeru Nakajima

Suppressed fat accumulation in rats fed with histidine-enriched diet

富含组氨酸饮食的大鼠可抑制脂肪堆积

• 发表时间: 2010
• 期刊: Journal of Food Science and Nutrition 15(In press)
• 作者: Endo M;Kasaoka S;Takizawa M;Goto K;Nakajima S;Moon S-K;Kim;I-S;Jeong B-Y;Nakamura S
• 通讯作者: Nakamura S

Negative correlations between free histidine content in plasma and BMI or area of visceral fat

血浆中游离组氨酸含量与BMI或内脏脂肪面积呈负相关

• 发表时间: 2009
• 期刊: Journal of Physical Fitness, Nutrition and Immunology 18
• 作者: Yuko Amamiya;Shigeru Nakajima;Keiichi Ikeda;Naoki Shida;Fumiyuki Yamakura;Sachio Kawai;Yuji Nakazato;Shizuo Katamoto;Isamu Kabe;Takahide Tsuchiya;Hideaki Iwa
• 通讯作者: Hideaki Iwa

Negative correlations between free histidine cintent in plasma and BMI or area if visceral fat

血浆中游离组氨酸浓度与BMI或内脏脂肪面积呈负相关

• 发表时间: 2009
• 期刊: Journal of Physical Fitness, Nutrition and Immunology 18
• 作者: Amamiya Y;Nakajima S;Ikeda K;Shida N;Yamakura F;Kawai S;Nakazato Y;Katamoto S;K abe I;Tsuchiya T;Iwai H
• 通讯作者: Iwai H