A research for a development of histopathological diagnosis method for schizophrenia on forensic autopsied brains

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On this research, multi-lectin positive spherical shaped deposits detected in the hippocampal formation of degenerative demented and schizophrenic brains were examined by mean of multi-fluorescent immunohistochemical and lectin histochemical method and immuno electron microscope method. These deposits were detected in cholinergic and glutamatergic neurons and D-neuron at the stage of apoptosis. This result and theories of insufficient migration of neurons in schizophrenic brains are in harmony, which suggests the lectin positive spherical shaped deposits detected in the hippocampal formation is a predominant histopathological marker of the postmortem diagnosis for schizophrenia.