Molecular basis of hyperthermia-thorough investigation into a newly identified heat-shock induced protein

具有序列相似性的家族107(FAM107)由哺乳动物中的FAM107A和B两个亚型组成。关于FAM107A作为候选抑癌基因的新数据已经积累起来，尽管关于另一个FAM107家族蛋白FAM107B的生物学信息很少。我们已经报道了FAM107B在肿瘤中的表达下调，并被热休克刺激诱导，并将其命名为热休克诱导的肿瘤小蛋白(HITS)。由于HITS的强制表达抑制了肿瘤的生长，因此HITS可能是一个潜在的肿瘤抑制基因，这与以前所描述的其他热休克蛋白的致癌活性形成了鲜明的对比。

Family with sequence similarity 107 (FAM107) consists of two subtypes of FAM107A and B in mammals. Emerging data regarding FAM107A as a candidate tumor suppressor gene have been accumulated, although few biological information is available about the other FAM107 family protein, FAM107B. We have reported that FAM107B expression was downregulated in cancer and induced by heat-shock stimulation, and designated it as heat shock-inducible tumor small protein (HITS). Since forced expression of HITS inhibited tumor growth, HITS would be a potential tumor suppressor gene, which contrasts with previously described oncogenic activities of other heat shock proteins.