Control of chronic hepatitis by splicing variant of hepatitis B virus

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1. Nucleic or amino acid substitutions in the core gene of hepatitis B virus (HBV) core region were studied. (1) Smaller number of nucleic acid substitutions in the basic core promoter region was associated with inactivation of hepatitis. (2) Larger number of substituted amino acid in the core region was associated with inactivation of hepatitis.2. The amino acid sequences of HBV splicing variant clones were analyzed. The majority of HBV clones had deletions spanning from end of core to preS-s regions (nt.2448～2934、3019～488). Six splicing patterns were found in the clones, three of which had large deletion (67AA, 87AA) in the core region.