Comprehensive gene expression analysis of cancer-infiltrating lymphocytes and peripheral blood cells for elucidation of cancer immunity kinesis

癌症浸润淋巴细胞和外周血细胞的综合基因表达分析，以阐明癌症免疫运动

• 批准号: 20590766
• 负责人: SAKAI Yoshio
• 金额: $ 2.5万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590766/
• 关键词: 肝臓学; 遺伝子発現; 肝癌; 癌免疫

Using murine subcutaneous hapatoma model which shows the proliferating and succeeding extinguishing phases, analysis of gene expression profile for local cancer-infiltrating inflammatory cells as well as peripheral blood cells was performed. The features of gene expression profiles for peripheral blood were distinct depending on the groups divided by the days after cancer cells injection. The common feature of gene expression of local cancer-infiltrating inflammatory cells as well as peripheral blood cells for mice with the tumors at the maximum size levels showed IL-6 signal and response to unfoleded proteins. As for the individually characteristic processes of gene expression, interferon signaling, NK cell cytotoxicity, complement system for local cancer-infiltrating inflammatory cells, and IL-10 anti-inflammatory response, amphoterin signaling for peripheral blood, were featured, respectively. These suggest that comprehensive analysis of gene expression of local cancer inflammatory response and peripheral blood cells will reveal the common as well as the distinguished features of local and systemic inflammatory responses.

使用显示增殖期和随后的熄灭期的小鼠皮下肝细胞瘤模型，对局部癌浸润炎性细胞以及外周血细胞的基因表达谱进行分析。外周血的基因表达谱的特征根据癌细胞注射后的天数划分的组而不同。局部癌症浸润性炎性细胞以及具有最大尺寸水平肿瘤的小鼠的外周血细胞的基因表达的共同特征显示IL-6信号和对未折叠蛋白的反应。至于基因表达的个别特征过程，干扰素信号传导、NK细胞的细胞毒性、局部癌症浸润炎性细胞的补体系统以及外周血的IL-10抗炎反应、白介素信号传导分别具有特征。综合分析肿瘤局部炎症反应和外周血细胞的基因表达，可以揭示局部和全身炎症反应的共同特征和区别。

项目成果

肝癌浸潤リンパ球の遺伝子発現プロファイルの特徴と、それが及ぼす肝癌患者末梢血液単核球細胞への影響

肝癌浸润淋巴细胞基因表达谱特征及其对肝癌患者外周血单个核细胞的影响

• 发表时间: 2008
• 作者: 酒井佳夫;本多政夫;藤永晴夫;小村卓也;辰巳勇;水腰英四郎;中本安成;金子周一
• 通讯作者: 金子周一

消化器癌における全血遺伝子発現の特徴

胃肠道肿瘤全血基因表达特征

• 发表时间: 2010
• 作者: 酒井佳夫;本多政夫;金子周一
• 通讯作者: 金子周一

Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C

• DOI: 10.1016/j.jhep.2010.04.036
• 发表时间: 2010-11-01
• 期刊: JOURNAL OF HEPATOLOGY
• 影响因子: 25.7
• 作者: Honda, Masao;Nakamura, Mikiko;Kaneko, Shuichi
• 通讯作者: Kaneko, Shuichi

CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes.

• DOI: 10.2337/db09-0659
• 发表时间: 2010-03
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Komura T;Sakai Y;Honda M;Takamura T;Matsushima K;Kaneko S
• 通讯作者: Kaneko S

Altered Hepatic Gene Expression Profiles Associated With Myocardial Ischemia

• DOI: 10.1161/circgenetics.108.795484
• 发表时间: 2010-02-01
• 期刊: CIRCULATION-CARDIOVASCULAR GENETICS
• 作者: Ootsuji, Hiroshi;Honda, Masao;Takamura, Masayuki
• 通讯作者: Takamura, Masayuki