Role of adiponectin in the development of liver cancer

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Recently, the metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, is reported to increase the risk of hepatocarcinogenesis. Although adiponectin is a plasma protein secreted from adipose tissue with known anti-diabetic and anti-atherogenic properties, its role in the development of liver cancer has remained unclear. In our current study, we investigated the growth of the transplanted liver tumors in the adiponectin knock out (KO) mice and demonstrated that KO mice showed the increased proliferation of liver tumors. These data indicated the possible anti-tumor role of adiponcetin in the development of liver cancer.