Analysis of newly recognized amplified region in 1q21p in hepatocellular carcinoma

我们认为，肝癌细胞基因组的变化与肝癌细胞的生长或恶变密切相关。我们已经报道了位于CREB/ATF家族1q21p的CREB3L4(cAMP反应元件结合蛋白3样蛋白)在肝癌组织中高水平表达。在进一步的研究过程中，我们发现转录辅助因子P300的核表达与人肝癌的血管侵袭和肝内转移密切相关。此外，我们还发现P300在肝细胞癌中的高表达与上皮间充质转化样表型改变和细胞周期蛋白D1/β-连环蛋白依赖性生长有关，这可能是导致患者预后不良的原因之一。

We believed that the changes in the genomes derived from HCC were deeply involved in the growth or malignant transformation of HCC cells. We have already reported that CREB3L4(cyclic AMP responsive element binding protein 3-like 4) located in 1q21p, which belonged to the CREB/ATF family, was amplified and was expressed in high levels in HCC samples. In the process of further research, we found that the nuclear expression of P300, a transcriptional co-factor, was associated with the vascular invasion and intrahepatic metastasis of human HCCs. Furthermore, we identified that high expression of P300 in HCC was associated with epithelial mesenchymal transition-like phenotypic change and cyclin D1/beta-catenin dependent growth of HCC cells which might explain the poor prognosis of the patients.