Analysis of newly recognized amplified region in 1q21p in hepatocellular carcinoma

肝细胞癌1q21p新识别扩增区域分析

• 批准号: 20590790
• 负责人: ITOH Yoshito
• 金额: $ 2.91万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590790/
• 关键词: 肝臓学; 肝細胞癌; 遺伝子増幅領域; マイクロアレイ; 遺伝子幅域

We believed that the changes in the genomes derived from HCC were deeply involved in the growth or malignant transformation of HCC cells. We have already reported that CREB3L4(cyclic AMP responsive element binding protein 3-like 4) located in 1q21p, which belonged to the CREB/ATF family, was amplified and was expressed in high levels in HCC samples. In the process of further research, we found that the nuclear expression of P300, a transcriptional co-factor, was associated with the vascular invasion and intrahepatic metastasis of human HCCs. Furthermore, we identified that high expression of P300 in HCC was associated with epithelial mesenchymal transition-like phenotypic change and cyclin D1/beta-catenin dependent growth of HCC cells which might explain the poor prognosis of the patients.

我们认为源自HCC的基因组的变化与HCC细胞的生长或恶性转化密切相关。我们已经报道，位于1q21p的CREB3L4（环状AMP反应元件结合蛋白3-like 4）属于CREB/ATF家族，在HCC样本中被扩增并高水平表达。在进一步的研究过程中，我们发现转录辅助因子P300的核表达与人肝癌的血管侵袭和肝内转移相关。此外，我们发现 HCC 中 P300 的高表达与上皮间质转化样表型变化和 HCC 细胞的细胞周期蛋白 D1/β-连环蛋白依赖性生长有关，这可能解释了患者的不良预后。

项目成果

ERK5 is a target for gene amplification at 17q11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry

ERK5 是 17q11 基因扩增的靶标，通过调节有丝分裂进入促进肝细胞癌的细胞生长

• 发表时间: 2009
• 期刊: Genes Chromosomes Cancer 48
• 作者: Zen K;et al.
• 通讯作者: et al.

Infrequent amplification of JUN in hepatocellular carcinoma.

• 发表时间: 2009-12
• 期刊: Anticancer research
• 影响因子: 2
• 作者: Mio Endo;K. Yasui;T. Nakajima;Y. Gen;Kazuhiro Tsuji;O. Dohi;Keika Zen;H. Mitsuyoshi;M. Minami;Y. Itoh;M. Taniwaki;Shinji Tanaka;S. Arii;T. Okanoue;T. Yoshikawa

細胞癌におけるtranscriptional cofactor P300の発現とその臨床的意義

转录辅助因子P300在细胞癌中的表达及其临床意义

• 发表时间: 2011
• 作者: 横溝千尋;山口寛二;新美敏久;西村健;藤井秀樹;吉川敏一;伊藤義人
• 通讯作者: 伊藤義人

High expression of P300 in HCC is associated with EMT-like phenotypic change and cyclin D1/beta-catenin dependent growth of HCC cells which may underlie poor prognosis of the patients

HCC 中 P300 的高表达与 HCC 细胞的 EMT 样表型变化和细胞周期蛋白 D1/β-连环蛋白依赖性生长相关，这可能是患者预后不良的原因

• 发表时间: 2011
• 作者: Yokomizo C;Yamaguchi K;Nishimura T;N Tochiki;Fujii H;Nakajima T;Umemura A;Okanoue T;Itoh Y
• 通讯作者: Itoh Y

High Expression of A Transcriptional Cofactor P300 in HCC Down-Regulates E-Cadherin, Promotes Tumor Invasion, And Predicts Shortened Overall Survival Of HCC Patients

HCC 中转录辅因子 P300 的高表达下调 E-钙粘蛋白，促进肿瘤侵袭，并预测 HCC 患者总生存期缩短

• 发表时间: 2010
• 作者: Yokomizo C;Itoh Y;Yamaguchi k;Nishimura T;Okanoue T;Yoshikawa T
• 通讯作者: Yoshikawa T