Association of plasma S100A12 level with cardiovascular diseases.

血浆 S100A12 水平与心血管疾病的关联。

基本信息

  • 批准号:
    20590846
  • 负责人:
  • 金额:
    $ 2.91万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2008
  • 资助国家:
    日本
  • 起止时间:
    2008 至 2011
  • 项目状态:
    已结题

项目摘要

In end stage renal disease(ESRD) patients, we found that mean plasma S100A12 level was 2.3-fold higher than that in control subjects and that this level was an independent factorassociated with the prevalence of atherosclerotic cardiovascular diseases(CVD) such as ischemic heart disease including myocardial infarction and angina pectoris, symptomatic stroke and symptomatic peripheral vascular disease. Therefore, we anticipate an important role for S100A12 as a novel biomarker to predict CVD in patients with ESRD. Prospective and interventional studies are currently ongoing to further elucidate the relationship between plasma S100A12 level and CVD.
终末期肾病(ESRD)患者血浆S100A12水平是对照组的2.3倍,是缺血性心脏病(包括心肌梗死和心绞痛)、症状性脑卒中和症状性外周血管病等动脉粥样硬化性心血管疾病(CVD)发病的独立相关因素。因此,我们预期S100A12作为一种新的生物标志物在预测ESRD患者的CVD中具有重要作用。目前正在进行前瞻性和干预性研究,以进一步阐明血浆S100A12水平与CVD之间的关系。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease.
  • DOI:
    10.1159/000335198
  • 发表时间:
    2011-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shiotsu Y;Mori Y;Hatta T;Maki N;Iida K;Matsuoka E;Kado H;Ishida R;Kishimoto N;Tamagaki K;Nishimura M;Iwamoto N;Ono T;Matsubara H;Kosaki A
  • 通讯作者:
    Kosaki A
Increased plasma S100A12 level is associated with cardiovascular diseases in hemodialysis patients
血液透析患者血浆S100A12水平升高与心血管疾病相关
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yayoi Shiotsu
  • 通讯作者:
    Yayoi Shiotsu
Increased plasma S100A12 level is associated with cardiovascular diseases in non-diabetic hemodialysis patients.
血浆 S100A12 水平升高与非糖尿病血液透析患者的心血管疾病相关。
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mori Y;Shiotsu Y;Kosaki A
  • 通讯作者:
    Kosaki A
Increased plasma S100A12 level is associated with cardiovascular diseases in hemodialysis patients.
血液透析患者血浆S100A12水平升高与心血管疾病相关。
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mori Y;Shiotsu Y;Nishimura M;Hatta T;Maki N;Iida K;Matsubara H;Kosaki A
  • 通讯作者:
    Kosaki A
Plasma S100A12 Concentrations in Peritoneal Dialysis Patients and Subclinical Chronic Inflammatory Disease
腹膜透析患者和亚临床慢性炎症性疾病的血浆 S100A12 浓度
  • DOI:
    10.1111/j.1744-9987.2007.00537.x
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    1.9
  • 作者:
    Y. Uchiyama‐Tanaka;Y. Mori;A. Kosaki;Tatsuji Kimura;Misaki Moriishi;H. Kawanishi;H. Matsubara
  • 通讯作者:
    H. Matsubara
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KOSAKI Atsushi其他文献

KOSAKI Atsushi的其他文献

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{{ truncateString('KOSAKI Atsushi', 18)}}的其他基金

High circulating S100A12 is a predictor for cardiovascular mortality in ESRD patients.
高循环 S100A12 是 ESRD 患者心血管死亡率的预测因子。
  • 批准号:
    24591078
  • 财政年份:
    2012
  • 资助金额:
    $ 2.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Efficacy of implantation of hematopoietic mononuclear cells on diabetic peripheral neuropathy and foot ulcer.
造血单核细胞植入治疗糖尿病周围神经病变和足溃疡的疗效。
  • 批准号:
    15590961
  • 财政年份:
    2003
  • 资助金额:
    $ 2.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Pathophysiological role of S100A12 protein via the receptor for advanced glycation end products(EN-RAGE)
S100A12 蛋白通过晚期糖基化终末产物受体 (EN-RAGE) 的病理生理作用
  • 批准号:
    13671203
  • 财政年份:
    2001
  • 资助金额:
    $ 2.91万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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Genetics of Cardiovascular Disease in Chronic Kidney Disease
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收缩压干预试验中可溶性 Klotho 与心血管疾病、慢性肾病进展和血压的关系
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