Clarification of molecular mechanisms of RANK/TRAF6 signaling pathways in osteoclastogenesis

点击翻译按钮获取中文摘要

Osteoclasts, which are bone-resorbing cells, play a pivotal role in maintenance of bone homeostasis. The formation of osteoclasts requires the signaling pathways mediated by the receptor protein, RANK. In the present study, I demonstrated that RANK has a novel functional domain that sustains its interaction with the downstream signaling factors. Furthermore, Treatment with the peptides containing the amino aid sequence of its domain significantly suppressed osteoclast formation. These findings might contribute to development of new treatments for bone diseases, such as osteoporosis.