Tissue specific function of liganded/unliganded VDR on inflammatory disease.

本研究旨在探讨维生素D受体(VDR)在炎症性疾病中的生物学作用。VDRKO小鼠和Cyp27b1KO小鼠在用葡聚糖硫酸钠(DSS)诱导结肠炎时表现出比WT小鼠更严重的表型。而VDRKO小鼠和Cyp27b1KO小鼠则无明显差异。这些数据表明，维生素D对VDR在结肠的生物学功能是不可或缺的，结合型VDR可以缓解炎症性肠病的症状。

The present study aims to find out biological functions of Vitamin D receptor (VDR) on inflammatory disease. VDRKO mice as well as Cyp27b1KO mice exhibit more severe phenotype than WT mice when treated with dextran sodium sulphate (DSS) to induce colitis. However no significant difference was observed in VDRKO mice and Cyp27b1KO mice. These data indicated that vitamin D is indispensable for biological function of VDR in colon and liganded VDR relieved the symptoms of inflammatory bowel disease.