Tissue specific function of liganded/unliganded VDR on inflammatory disease.

配体/未配体 VDR 对炎症性疾病的组织特异性功能。

• 批准号: 20780091
• 负责人: YAMAMOTO Yoko
• 金额: $ 2.75万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20780091/
• 关键词: 栄養化学; ビタミンD; VDR; 炎症性疾患; ビタミンD受容体; 転写制御; 栄養学

The present study aims to find out biological functions of Vitamin D receptor (VDR) on inflammatory disease. VDRKO mice as well as Cyp27b1KO mice exhibit more severe phenotype than WT mice when treated with dextran sodium sulphate (DSS) to induce colitis. However no significant difference was observed in VDRKO mice and Cyp27b1KO mice. These data indicated that vitamin D is indispensable for biological function of VDR in colon and liganded VDR relieved the symptoms of inflammatory bowel disease.

本研究旨在探讨维生素D受体(VDR)在炎症性疾病中的生物学作用。VDRKO小鼠和Cyp27b1KO小鼠在用葡聚糖硫酸钠(DSS)诱导结肠炎时表现出比WT小鼠更严重的表型。而VDRKO小鼠和Cyp27b1KO小鼠则无明显差异。这些数据表明，维生素D对VDR在结肠的生物学功能是不可或缺的，结合型VDR可以缓解炎症性肠病的症状。