Tissue specific function of liganded/unliganded VDR on inflammatory disease.

本研究旨在了解维生素D受体（VDR）在炎症性疾病中的生物学功能。用葡聚糖硫酸钠（DSS）诱导结肠炎时，VDRKO小鼠和Cyp27b1KO小鼠表现出比WT小鼠更严重的表型。然而，在VDRKO小鼠和Cyp27b1KO小鼠中没有观察到显著差异。这些数据表明维生素D对于VDR在结肠中的生物学功能是必不可少的，配体VDR可以缓解炎症性肠病的症状。

The present study aims to find out biological functions of Vitamin D receptor (VDR) on inflammatory disease. VDRKO mice as well as Cyp27b1KO mice exhibit more severe phenotype than WT mice when treated with dextran sodium sulphate (DSS) to induce colitis. However no significant difference was observed in VDRKO mice and Cyp27b1KO mice. These data indicated that vitamin D is indispensable for biological function of VDR in colon and liganded VDR relieved the symptoms of inflammatory bowel disease.