Development of Tandem Reactions for Synthesis of Heterocyclic Compounds via Palladium-Catalyzed 1,2-Addition

合成了新型的硫醚-咪唑卡宾配体，并证明了钯/硫醚-咪唑氯化铵体系是有机硼试剂与醛的1，2-加成反应的有效催化剂。该反应体系对水相反应条件具有较好的耐受性，是一种环境友好的合成方法。此外，还成功地实现了钯催化1，2-与硫醚-咪唑卡宾配体的1，2-加成反应合成3-芳基邻苯二甲酸酯。

Novel thioether-imidazolinium carbene ligands were developed and the palladium/thioether-imidazolinium chloride system was proved to be an efficient catalyst for the 1,2-addition reactions of organoboron reagents to aldehydes. This reaction system can be an environmentally benign synthetic method because of its tolerance for aqueous reaction conditions. In addition, efficient synthesis of 3-arylphthalides via palladium-catalyzed 1,2-addition with thioether-imidazolinium carbene ligands was successfully achieved.